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Bioorg Med Chem Lett
; 17(10): 2802-6, 2007 May 15.
Article
in English
| MEDLINE
| ID: mdl-17350259
ABSTRACT
Further structure-activity relationships of a novel series of fungal efflux pump inhibitors with respect to potentiation of the activity of fluconazole against strains of C. albicans and C. glabrata over-expressing ABC-type efflux pumps are systematically explored. Rat protein binding and pharmacokinetics of selected analogues are reported.