ABSTRACT
A bleeding diathesis need not be a contra-indication to elective surgical correction of facial deformities. Preoperative haemostatic assessment and management of haemostasis during and after surgery is described. Two cases of mild von Willebrand's disease and one case of factor XI deficiency who successfully underwent orthognathic surgery for the correction of facial deformities are reported.
Subject(s)
Face/abnormalities , Factor XI Deficiency/prevention & control , Hemostasis, Surgical , Osteotomy , von Willebrand Diseases/prevention & control , Adolescent , Adult , Face/surgery , Facial Asymmetry/surgery , Factor VIII/therapeutic use , Female , Humans , Male , Malocclusion/surgery , Maxilla/abnormalities , Maxilla/surgery , Plasma , Prognathism/surgerySubject(s)
Bone Marrow Transplantation , Leukemia, Myeloid, Acute/surgery , Adolescent , Adult , Clinical Trials as Topic , Female , Humans , Male , Middle Aged , Transplantation, AutologousABSTRACT
A 17 year old woman presented with severe anaemia due to menorrhagia. On investigation, she was shown to have abnormalities of her haemostatic mechanism consistent with von Willebrand's disease Type I, although there was no family history of this disorder. In addition, she was shown to have severe primary hypothyroidism. On correction of hypothyroidism with oral thyroxine, her coagulation defects returned to normal and menorrhagia ceased. This is consistent with acquired von Willebrand's disease secondary to hypothyroidism.
