1.
Bioorg Med Chem Lett
; 18(1): 252-5, 2008 Jan 01.
Article
in English
| MEDLINE
| ID: mdl-18006308
ABSTRACT
A series of novel 2-alkoxy- and 2-aryloxyiminoalkyl trifluoromethanesulfonanilide derivatives have shown significant in vitro parasiticidal activity against the ectoparasites Ctenocephalides felis and Rhipicephalus sanguineus. A number of these compounds also displayed significant in vitro endoparasite activity against the nematode Haemonchus contortus.
Subject(s)
Antiparasitic Agents/chemistry , Antiparasitic Agents/pharmacology , Rhipicephalus sanguineus/drug effects , Siphonaptera/drug effects , Sulfonamides/chemistry , Sulfonamides/pharmacology , Animals , Haemonchus/drug effects , Structure-Activity Relationship
2.
Bioorg Med Chem Lett
; 17(4): 993-7, 2007 Feb 15.
Article
in English
| MEDLINE
| ID: mdl-17150358
ABSTRACT
A series of 2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives were synthesized and evaluated for in vitro activity against the endoparasite Haemonchus contortus and the ectoparasite Ctenocephalides felis. Some compounds had significant in vitro activity against these parasites.