Subject(s)
Antitubercular Agents/administration & dosage , Carcinoid Tumor , Lung , Photochemotherapy/methods , Pneumonectomy/methods , Tuberculosis, Pulmonary , Bronchoscopy/methods , Carcinoid Tumor/complications , Carcinoid Tumor/diagnostic imaging , Carcinoid Tumor/physiopathology , Carcinoid Tumor/surgery , Drug Administration Schedule , Drug Monitoring , Humans , Lung/pathology , Lung/surgery , Male , Patient Care Planning , Positron-Emission Tomography , Preoperative Care/methods , Tomography, X-Ray Computed , Treatment Outcome , Tuberculosis, Pulmonary/complications , Tuberculosis, Pulmonary/drug therapy , Tuberculosis, Pulmonary/physiopathology , Tuberculosis, Pulmonary/radiotherapy , Tuberculosis, Pulmonary/surgery , Young AdultABSTRACT
The lung and lymph nodes were examined in 130 patients aged 19-70 years, who had been operated on at the Department of Surgery, Saint Petersburg Research Institute of Phthisiology, for pulmonary tuberculosis. The immunopathological changes have close correlations in the bronchi and pulmonary respiratory parenchyma. This gives grounds to regard the lung and lymph nodes jointly as the organ of local immunity (sui generis) and to suggest that there is a synergism of immune reactions. Every gross organism prefers this or that line of development of an inflammatory process in the lung. This choice is predetermined genetically, on the one hand, and caused by other factors, on the other. The latter include the duration of disease, its inclination for the undulating course, and a rather steady-state high activity of inflammation along with concomitant bronchopulmonary pathology that in turn varying in manifestations, depending on the morphofunctional status of BALT. The development of specific bronchial damage in the presence of nonspecific bronchitis argues for the key impact of BALT.
Subject(s)
Bronchi/immunology , Bronchi/pathology , Lymph Nodes/immunology , Tuberculosis, Pulmonary/immunology , Tuberculosis, Pulmonary/pathology , Adult , Aged , Algorithms , Humans , Hyperplasia , Middle Aged , Tuberculosis, Pulmonary/surgeryABSTRACT
A histological examination of the pulmonary and bronchopulmonary lymph nodes was made in 47 patients treated surgically for fibrocavernous pulmonary tuberculosis. The speed of immunopathological reactions development is the main reason of differences between drug-resistant and drug-sensitive primary tuberculosis. Formation of cellular immunity in drug-resistant tuberculosis has all necessary morphological prerequisites both in the lungs and lymph nodes but their realization is delayed. Immunogenesis concentrates on the early stages when initial paraspecific reactions prevail. Morphologically, they are most demonstrative in the bronchial walls where in different patients or even in one patient but in various bronchi all reactions of delayed type (contact, tuberculine type and granulematous) can be simultaneously observed.
