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1.
Mult Scler Relat Disord ; 51: 102874, 2021 Jun.
Article in English | MEDLINE | ID: mdl-33714127

ABSTRACT

Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a distinct pathologic entity of unknown etiology. Here, we describe the clinical and radiologic presentation of myelin oligodendrocyte glycoprotein associated disease (MOG-AD) with features mimicking CLIPPERS. Three patients met the 2017 CLIPPERS diagnostic criteria, while one patient had a single lesion in the pons that mimicked CLIPPERS lesions. All had an excellent response to steroids, but the three who met the CLIPPERS criteria had a relapsing course. When CLIPPERS is observed, it is crucial to test for mimickers. The ever-expanding spectrum of MOG-AD calls for further research into the immunopathogenesis of its several phenotypes.


Subject(s)
Magnetic Resonance Imaging , Pons , Humans , Myelin-Oligodendrocyte Glycoprotein , Pons/diagnostic imaging , Steroids
2.
Mult Scler Relat Disord ; 44: 102308, 2020 Sep.
Article in English | MEDLINE | ID: mdl-32575025

ABSTRACT

The clinical and radiological spectrum of myelin oligodendrocyte glycoprotein (MOG) antibody associated disease continues to expand. Here, we describe a case of prolonged, relapsing, intractable nausea and vomiting misdiagnosed as a functional disorder for more than one year. The patient did not receive a neurological workup until clear neurological signs developed. This case exemplifies the delay in diagnosis when neurological disease presents with seemingly non-neurological symptoms and illustrates brainstem and upper spinal cord radiological findings that can help guide the treating physician to test for MOG antibodies and provide the appropriate treatment.


Subject(s)
Antibodies , Brain Stem , Autoantibodies , Brain Stem/diagnostic imaging , Humans , Myelin-Oligodendrocyte Glycoprotein , Nausea/etiology , Vomiting
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