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Tissue Antigens ; 84(5): 484-8, 2014 Nov.
Article in English | MEDLINE | ID: mdl-25209617

ABSTRACT

We have characterized swine leucocyte antigen (SLA) classes I and II molecules of a domestic pig as a model for use in our xenotransplant program. Molecular characterization of the SLA classes I and II genes is critical to understanding the adaptive immune responses between swine and humans in the event of xenotransplantation. Seven swine leucocyte antigen genes (SLA-1, SLA-2, SLA-3, DQB1, DRB1, DQA and DRA) were analyzed and 15 alleles were identified. A novel DRA*w04re01 is reported for this limited polymorphic class II gene. The heterozygous haplotypes, Hp-32.0/35.0 and Hp-0.13/0.23 were deduced for our IU-pig model, for SLA classes I and II regions, respectively.


Subject(s)
Alleles , Haplotypes , Heterozygote , Histocompatibility Antigens Class II/genetics , Histocompatibility Antigens Class I/genetics , Swine/genetics , Adaptive Immunity , Animals , Crosses, Genetic , Histocompatibility Antigens Class I/immunology , Histocompatibility Antigens Class II/immunology , Swine/immunology
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