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Clin Ter ; 150(2): 103-7, 1999.
Article in Italian | MEDLINE | ID: mdl-10396858

ABSTRACT

PURPOSE: To compare the results, in terms of 10-year actuarial survival, between I-131-therapy and I-131-therapy + external beam radiotherapy (RT) in patients operated on for differentiated thyroid carcinoma. PATIENTS AND METHODS: Over a period of 13 years (1982-1995) 408 patients underwent thyroidectomy with or without linphoadenectomy for pT0/T4 Nx or pN0, pN1a, pN1b thyroid carcinoma. In all cases, thyroidectomy was radical. Patients were divided into two groups, which were comparable according to several prognostic factors: group A composed of 165 patients (surgery + I-131) and group B, 243 patients (surgery + I-131 + RT). RESULTS: The percentage of deaths related to relapsed or metastatic thyroid carcinoma was 6.25%. In the group treated with adjuvant radiotherapy, 14.8% of the patients experienced acute tracheal or esophageal side effects. Late toxicity (mouth dryness, skin and/or muscle fibrosis) was recorded only in a small percentage of the patients (2.4%). CONCLUSIONS: Adjuvant RT resulted in a statistically significant improvement (p < 0.01) in survival of patients with extracapsular diffusion of the cancer, especially those with pT4 N1b tumors or tumors involving the trachea.


Subject(s)
Carcinoma/surgery , Thyroid Neoplasms/surgery , Carcinoma/pathology , Carcinoma/radiotherapy , Cell Differentiation , Humans , Neoplasm Metastasis , Postoperative Care , Thyroid Neoplasms/pathology , Thyroid Neoplasms/radiotherapy , Thyroidectomy , Treatment Outcome
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