Subject(s)
Acceleration/adverse effects , Chromosome Aberrations , Immobilization , Lymphocytes/ultrastructure , Adult , Humans , Male , Middle Aged , Time FactorsSubject(s)
Acceleration/adverse effects , Chromosome Aberrations , Immobilization , Adult , Humans , Lymphocytes/ultrastructure , Male , Middle AgedSubject(s)
Chromosome Aberrations , Hypoxia/genetics , Altitude , Animals , Gene Frequency , Male , Mice , Mitosis , Mutation , Polyploidy , Time FactorsABSTRACT
The paper presents the results of an exposure of cells of the Syrian hamster strain VNK-21 to space flight effects. In contrast to the cell culture kept in a thermostat at 29 degrees C, the cell culture that was maintained in thermally uncontrolled conditions developed noticeable structural and physiological changes induced by suboptimal temperatures. It was concluded that a 6-day exposure to weightlessness exerted no adverse effect on mammalian cells in vitro and produced no stable structural or physiological changes. Some changes that were detected in the cell culture--faster ageing, stable tendency to an increase of the number of cells with enlarged nuclei, an increase of the mitotic index at an early stage of cultivation--need further investigation.
Subject(s)
Cell Nucleus , Mitosis , Space Flight , Cell Line , TemperatureABSTRACT
The results of cytogenetic investigation of 14 crewmembers of "Soyuz" spacecrafts before and after 7 spaceflights are represented. No cytogenetic changes were noted at the investigated crewmembers on the first postflight day as compared to the preflight data. Possible causes of differences between the author's data and the data of foreign investigators on cytogenetic investigation of American crewmembers are discussed in the article.
