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Tris-2(hydroxyethyl)ammonium (2-methylphenoxy)acetate as an inhibitor of synthesis of acid phospholipase A2 of mononuclear cells.

Rasulov, M M; Bobkova, S N; Belikova, O A; Nurbekov, M K; Voronkov, M G.

Dokl Biochem Biophys ; 444: 137-9, 2012.

Article in English | MEDLINE | ID: mdl-22772994

Subject(s)

Monocytes/enzymology , Phenoxyacetates/pharmacology , Phospholipase A2 Inhibitors , Phospholipases A2/biosynthesis , Quaternary Ammonium Compounds/pharmacology , Animals , Atherosclerosis/blood , Atherosclerosis/drug therapy , Atherosclerosis/enzymology , Cholesterol/blood , Disease Models, Animal , Injections, Intramuscular , Lipoproteins/blood , Monocytes/drug effects , Phospholipases A2/metabolism , Rabbits , Triglycerides/blood

Tris-2(hydroxyethyl) ammonium 2-methylphenoxyacetate as an inhibitor of synthesis of liver phospholipase A1.

Bobkova, S N; Rasulov, M M; Nurbekov, M K; Belikova, O A; Shimanovskaya, N P; Voronkov, M G.

Dokl Biochem Biophys ; 440: 219-20, 2011.

Article in English | MEDLINE | ID: mdl-22095123

Subject(s)

Atherosclerosis/complications , Enzyme Inhibitors/pharmacology , Liver Diseases/drug therapy , Liver/enzymology , Phenoxyacetates/pharmacology , Phospholipases A1/antagonists & inhibitors , Phospholipases A1/metabolism , Quaternary Ammonium Compounds/pharmacology , Animals , Atherosclerosis/metabolism , Cholesterol/metabolism , Disease Models, Animal , Lipoproteins, LDL/metabolism , Liver/drug effects , Liver Diseases/etiology , Liver Diseases/metabolism , Phospholipases A1/drug effects , Rabbits , Triglycerides/metabolism

Tris-2(hydroxyethyl) ammonium 2-methylphenoxyacetate as an activator of aorta intima acid lipase.

Voronkov, M G; Bobkova, S N; Rasulov, M M; Nurbekov, M K; Belikova, O A.

Dokl Biochem Biophys ; 440: 211-2, 2011.

Article in English | MEDLINE | ID: mdl-22095120

Subject(s)

Atherosclerosis/metabolism , Enzyme Activators/pharmacology , Lipase/drug effects , Lipase/metabolism , Phenoxyacetates/pharmacology , Quaternary Ammonium Compounds/pharmacology , Tunica Intima/enzymology , Animals , Aorta/chemistry , Aorta/enzymology , Atherosclerosis/chemically induced , Cholesterol/metabolism , Disease Models, Animal , Lipoproteins, LDL/metabolism , Rabbits , Triglycerides/metabolism , Tunica Intima/chemistry

Tris-2(hydroxyethyl)ammonium 2-methylphenoxyacetate activates the synthesis of mRNA aminoacyl-tRNA synthetase.

Nurbekov, M K; Rasulov, M M; Voronkov, M G; Bobkova, S N; Belikova, O A.

Dokl Biochem Biophys ; 438: 131-3, 2011.

Article in English | MEDLINE | ID: mdl-21725890

Subject(s)

Amino Acyl-tRNA Synthetases/metabolism , Phenoxyacetates/pharmacology , Quaternary Ammonium Compounds/pharmacology , RNA, Messenger/biosynthesis , Amino Acyl-tRNA Synthetases/genetics , Animals , Cells, Cultured , Gene Expression Regulation/drug effects , Humans , Rabbits

Tris-2(hydroxyethyl)ammonium (2-methylphenoxy)acetate as an inhibitor of synthesis of acid cholesterol esterase of platelets and mononuclear cells.

Rasulov, M M; Bobkova, S N; Belikova, O A; Nurbekov, M K; Shimanovskaya, N P; Voronkov, M G.

Dokl Biochem Biophys ; 441: 270-2, 2011.

Article in English | MEDLINE | ID: mdl-22218952

Subject(s)

Atherosclerosis/drug therapy , Atherosclerosis/metabolism , Blood Platelets/enzymology , Monocytes/enzymology , Phenoxyacetates/pharmacology , Quaternary Ammonium Compounds/pharmacology , Sterol Esterase/metabolism , Animals , Blood Coagulation/drug effects , Blood Platelets/drug effects , Disease Models, Animal , Lipid Metabolism/drug effects , Monocytes/drug effects , Rabbits , Sterol Esterase/drug effects

Antisclerotic effect of Trekrezan and its possible mechanisms.

Voronkov, M G; Nurbekov, M K; Bobkova, S N; Karaulova, L K; Susova, M I; Rasulov, M M.

Dokl Biochem Biophys ; 431: 73-5, 2010.

Article in English | MEDLINE | ID: mdl-20514866

Subject(s)

Acetates/pharmacology , Atherosclerosis/drug therapy , Ethanolamines/pharmacology , Animals , Aorta/drug effects , Aorta/pathology , Aorta, Thoracic/pathology , Atherosclerosis/physiopathology , Body Weight , Cholesterol/metabolism , Drug Combinations , Drug Evaluation, Preclinical , Lipids/chemistry , Lipoproteins, LDL/chemistry , Liver/drug effects , Rabbits , Temperature , Time Factors , Triglycerides/metabolism

[Comparative evaluation of hypolipidemic effects of omega-3 polyunsaturated acids and lipostabil]. / Sravnitel'naia otsenka gipolipidemicheskogo deistviia polinenasyshchennykh zirnykh kislot omega-3 i lipopstabila.

Pogozheva, A V; Bobkova, S N; Samsonov, M A; Vasil'ev, A V.

Vopr Pitan ; (4): 31-3, 1996.

Article in Russian | MEDLINE | ID: mdl-8984798

ABSTRACT

Comparative effect of eiconol (resource of omega-3 PUFA) and lipostabil on lipid, biochemical, hemostatic parameters in blood and activity of lipolytic enzymes in thrombocytes and monocytes was studied in 18 clinic patients with ischemic heart disease fed antiatherosclerotic diet during 2 weeks. On basis of these parameters was concluded that eiconol and lipostabil showed the strong hypolipidemic effect. Fibrinolytic effect showed only eiconol. The results showed that hypolipidemic and fibrinolytic actions more strong at treatment by eiconol.

Subject(s)

Dietary Fats, Unsaturated/therapeutic use , Fish Oils/therapeutic use , Hypolipidemic Agents/therapeutic use , Phosphatidylcholines/therapeutic use , Fibrinolysis , Humans , Male , Middle Aged , Myocardial Ischemia/diet therapy , Myocardial Ischemia/drug therapy , Myocardial Ischemia/metabolism , Time Factors

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