ABSTRACT
In sheep with adenomatosis, enhanced activity is exhibited by both the central and peripheral organs of immunity. Histologic manifestations of this in the thymus include blast transformation of the T and B zones, numerous mitoses, elevated numbers of unicellular thymus corpuscles, and accumulations of thymocytes around these corpuscles and capillaries, while in the lymph nodes and spleen they include many mitoses in the reactive centers of lymphatic follicles and in the mentle and marginal zones, and increased numbers of lymphocytes, neutrophils, plasma cells, and PAS-positive cells. The intensified functioning of lymphoid tissues combines with very pronounced phagocytic reactions in the immune organs and pulmonary parenchyma and with adenomatous proliferation.
