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1.
Phytomedicine ; 80: 153368, 2021 Jan.
Article in English | MEDLINE | ID: mdl-33091857

ABSTRACT

BACKGROUND: The most common symptoms of mild upper respiratory tract infections (URTIs) are sore throat, muffled dysphonia, and swelling and redness of the throat, which result from the inflammation process following acute bacterial or viral infection. HYPOTHESIS/PURPOSE: As propolis is a natural resinous substance traditionally used to maintain oral cavity and upper respiratory tract health due to its antimicrobial and anti-inflammatory properties, the aim of this study is to evaluate the efficacy of an oral spray based on poplar-type propolis extract with a known and standardized polyphenol content, on the remission of the symptoms associated with mild uncomplicated URTIs. STUDY DESIGN: A monocentric, randomized, double-blind, placebo-controlled clinical trial was performed. METHODS: This study was conducted in 122 healthy adults who had perceived mild upper respiratory tract infections. Participants, randomly assigned to receive either propolis oral spray (N = 58) or placebo (N = 64), underwent four visits (baseline = t0, after 3 days = t1 and after 5 days = t2 and after a follow-up of 15 days = t3) in an outpatient setting. Propolis oral spray total polyphenol content was 15 mg/ml. The dosage was 2-4 sprays three times/day (corresponding to 12-24 mg of polyphenols/day), for five days. The duration of the study was 8 weeks. RESULTS: After 3 days of treatment, 83% of subjects treated with propolis oral spray had remission of symptoms, while 72% of subjects in the placebo group had at least one remaining symptom. After five days, all subjects had recovered from all symptoms. This means that resolution from mild uncomplicated URTIs took place two days earlier, instead of taking place in five days as recorded in the control group. There was no relationship between the ingestion of propolis oral spray or placebo and adverse reactions. CONCLUSION: Propolis oral spray can be used to improve both bacterial and viral uncomplicated URTI symptoms in a smaller number of days without the use of pharmacological treatment, leading to a prompt symptom resolution.


Subject(s)
Pharyngitis/drug therapy , Polyphenols/therapeutic use , Propolis/therapeutic use , Respiratory Tract Infections/drug therapy , Administration, Oral , Adolescent , Adult , Aged , Double-Blind Method , Female , Humans , Male , Middle Aged , Placebos , Polyphenols/analysis , Polyphenols/standards , Propolis/administration & dosage , Propolis/chemistry , Respiratory Tract Infections/etiology , Treatment Outcome , Young Adult
2.
Nutrients ; 11(1)2019 Jan 09.
Article in English | MEDLINE | ID: mdl-30634393

ABSTRACT

Atherosclerotic cardiovascular diseases are preferential targets of healthy diet and preventive medicine partially through strategies to improve lipid profile and counteract oxidative metabolites. Ninety individuals with cardiovascular disease (CVD) risk factors were randomized (1:1:1 ratio) to three arms, according to a four-week run-in, eight-week intervention, and four-week follow up study, testing the effects of a lactofermented Annurca apple puree (lfAAP), compared to unfermented apple puree (AAP) or probiotic alone (LAB) on plasma lipid profile and trimethylamine-N-oxide (TMAO) levels. By comparing the treatments, data indicated for the subjects tested with lfAAP a higher variation of the following serum parameters, in respect to the other treatment groups: high density lipoprotein cholesterol (HDL-C), +61.8% (p = 0.0095); and TMAO levels, -63.1% (p = 0.0042). The present study would suggest lfAAP as an effective functional food for beneficial control of plasma HDL-C and TMAO levels.


Subject(s)
Cholesterol, HDL/blood , Fruit/chemistry , Functional Food , Malus/chemistry , Methylamines/blood , Oxidative Stress , Adolescent , Adult , Aged , Blood Glucose/metabolism , Cardiovascular Diseases/prevention & control , Cholesterol, LDL/blood , Female , Fermented Foods , Follow-Up Studies , Humans , Male , Middle Aged , Polyphenols/analysis , Probiotics , Triglycerides/blood , Young Adult
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