ABSTRACT
A 41-year-old white woman had undifferentiated giant cell carcinoma of the thyroid, unsuccessfully treated with local cobalt therapy. She was given a five-drug combination of chemotherapy, responding rapidly with marked improvement, abatement of symptoms, resolution of the tumor, and eight-year survival to date.
Subject(s)
Antineoplastic Agents/administration & dosage , Giant Cell Tumors/drug therapy , Thyroid Neoplasms/drug therapy , Adult , Drug Therapy, Combination , Female , Giant Cell Tumors/mortality , Humans , Thyroid Neoplasms/mortalitySubject(s)
Bone Cysts , Zygoma , Adolescent , Bone Cysts/diagnostic imaging , Bone Cysts/pathology , Bone Cysts/surgery , Humans , Male , Radiography , Zygoma/diagnostic imaging , Zygoma/pathologyABSTRACT
A case is herin reported of a primary gastric choriocarcinoma occurring in an elderly woman associated with very high titers of circulating chorionic gonadotropin. Unlike the majority of previously reported cases, in which adenocarcinomatous components were present, the tumor in this case was purely trophoblastic. The clinicopathologic findings of the previously reported cases are summarized, along with the various theories of histogenesis.
Subject(s)
Choriocarcinoma/pathology , Stomach Neoplasms/pathology , Adult , Aged , Choriocarcinoma/blood , Chorionic Gonadotropin/blood , Female , Humans , Male , Middle Aged , Pregnancy , Stomach Neoplasms/bloodABSTRACT
A large retroperitoneal seminoma in a 42-year-old man is described, which appears to have arisen as a primary tumor at that site. The mechanism for the development of extragonadal germ cell tumors is discussed, and the criteria for their distinction from metastatic occult or regressed testicular neoplasms are re-emphasized. Awareness by clinicians of this entity may save individuals with this neoplasm from unnecessary orchiectomy.
