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1.
Vestn Ross Akad Med Nauk ; (12): 18-22, 1999.
Article in Russian | MEDLINE | ID: mdl-10709461

ABSTRACT

The composition of liposomal lipid phase preparation was selected. The optimum ratio of liposomal lipid phase components was found to produce a a human liposomal recombinant alpha 2-interferon-containing preparation by extrusion across the polycarbonate membranes. The study gave rise to a lyophilized sterile liposomal recombinant alpha 2-interferon preparation. The agent was shown to be stable and retains its antiviral activity within a year.


Subject(s)
Adjuvants, Immunologic/pharmacology , Drug Design , Drugs, Investigational , Interferon Type I/pharmacology , Drug Carriers , Humans , Interferon alpha-2 , Interferon-alpha , Interferons , Liposomes , Recombinant Proteins , Virus Diseases/drug therapy
2.
Vopr Virusol ; 32(1): 87-95, 1987.
Article in Russian | MEDLINE | ID: mdl-3554756

ABSTRACT

Identification of 10 cell lines of 6 insect species received by the cell culture collection of Molecular Biology Institute from different research institutions of the USSR was carried out by karyological analysis and determinations of the spectrum of isoforms of the following enzymes: glucose-6-phosphate dehydrogenase (G-6-PDH), lactate dehydrogenase (LDH), isocitrate dehydrogenase (ICDH), and superoxide dismutase (SOD). Nine out of the 10 cell lines examined were shown to be identical to those of gypsy moth. Possible ways of cell contamination with other cells in long-term cultivation and preparation of new lines were determined.


Subject(s)
Insecta/cytology , Virus Cultivation , Animals , Cell Line , Chromosome Banding/methods , Cytological Techniques , Glucosephosphate Dehydrogenase/analysis , Isocitrate Dehydrogenase/analysis , Isoenzymes/analysis , Karyotyping , L-Lactate Dehydrogenase/analysis , Metaphase , Superoxide Dismutase/analysis
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