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Turning off Bacillus cereus quorum sensing system with peptidic analogs.
Yehuda, Avishag; Slamti, Leyla; Bochnik-Tamir, Racheli; Malach, Einav; Lereclus, Didier; Hayouka, Zvi.
Chem Commun (Camb) ; 54(70): 9777-9780, 2018 Aug 28.
Article in English | MEDLINE | ID: mdl-30105347

ABSTRACT

We explored quenching of the PlcR-PapR quorum-sensing system in Bacillus cereus. We generated PapR7-peptidic derivatives that inhibit this system and thus the production of virulence factors, reflected by a loss in hemolytic activity, without affecting bacterial growth. To our knowledge, these peptides represent the first potent synthetic inhibitors of quorum-sensing in B. cereus.


Subject(s)
Bacillus cereus/genetics , Bacterial Proteins/pharmacology , Peptide Fragments/pharmacology , Quorum Sensing/drug effects , Regulon/drug effects , Amino Acid Sequence , Amino Acid Substitution , Animals , Bacillus cereus/metabolism , Bacillus thuringiensis/genetics , Bacterial Proteins/antagonists & inhibitors , Bacterial Proteins/chemical synthesis , Bacterial Proteins/chemistry , Hemolysin Proteins/antagonists & inhibitors , Humans , Peptide Fragments/chemical synthesis , Peptide Fragments/chemistry , Protein Engineering , Sheep , Trans-Activators/antagonists & inhibitors , Virulence Factors/antagonists & inhibitors
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