[THE BIOMARKERS OF MYOCARDIAL DAMAGE AND THEIR ROLE IN THE PROGRESSION OF HEART FAILURE (REVIEW)].

Despite the success achieved in the study and treatment of chronic heart failure, this syndrome still remains one of the most difficult and predictable unreliable pathologies. Moreover, in recent years there has been a tendency of growth of such patients. Based on the above, the attention of scientists focuses on new concepts that involve the study of new biomarkers of cardiac damage and the definition of their role in the progression of heart failure. Based on studies conducted by numerous authors, the paper analyzes the importance of new biomarkers of myocardial damage in the development of heart failure. The manuscript describes biomarkers of damage (troponin T, galectin 3, lipocalin, Cystatin C): nature: the causes and mechanisms of their growth, increase and activity. Biomarkers of myocardial damage are shown to have diagnostic and high predicted values. Their temporary definition provides additional information for stratifying the risks of possible complications. It also gives us the opportunity to allocate patients with high risks in a timely manner and eliminate possible adverse complications.

Investigation of pro- and antioxidative systems' changes in blood of patients with prostate tumours.

Great number of pathogenic processes, including cancer, are followed by disbalance between pro- and antioxidative systems. This is reflected on lipid peroxidation (LP). As a result diene conjugates - the primary products of peroxidation, cetodienes, trienes (secondary products), malondialdehyde (MDA) and Schiff's bases (the final products) are synthesized. Significant changes are expectable in functioning of antioxidant system on the background of tumour growth. The aim of the study was to investigate changes in the content of primary, secondary and final LP products and quantitative changes of main antioxidant of plasma - Ceruloplsmin (Cp) in blood of patients with prostate tumors (benign prostate hyperplasia (BPH), benign prostate hyperplasia with PING(3-4) regions and metastatic prostate adenocarcinoma (PCa). The tendency of diene conjugates reducing has been revealed compared with norm: The control group-->BPH-->benign prostate hyperplasia with PING(3-4)regions-->metastatic PCa. Level of cetodienes and trienes was sharply decreased in case of PCa. MDA content was increased in all cases we had studied, but it was significantly increased in benign prostate hyperplasia with PING(3-4) regions and PCa. Amount of Schiff's bases raised in lipid extracts in all cases of prostate cancer, especially in patients with benign prostate hyperplasia with PING(3-4) regions. Concentration of Cp was sharply increased in blood plasma of patients with malignant tumour. Strong intensification of LP in prostate cancer patients and accumulation of its final products occurs on the background of changes of the antioxidant system. This fact was revealed by sharp increase of Cp content in blood plasma of the patients. Both facts express disbalances of the anti- and prooxidative systems of organism in case of prostate gland malignant transformation.

[Proton magnetic resonance study of the changes in blood lipids in malignant and benign neoplasms]. / Issledovanie metodom protonnogo magnitnogo rezonansa izmeneniia soderzhaniia lipidov krovi pri zlokachestvennoi i dobrokachestvennoi opukholiakh.

High-resolution 1H-NMR spectrometry (360 MHz) was used in combination with thin layer chromatography to study changes in composition and molecular structure of inverted micelles of blood lipids from patients with breast and uterus cancer. Changes in relative intensity of NMR signals of lipids compared with norm were revealed. The changes in the lipid composition of blood components, in particular, in cholesterol content, determine the differences in structure and molecular mobility of these lipids, which probably explains the regularities observed in the NMR spectra.