1.
Angew Chem Int Ed Engl
; 46(31): 5916-20, 2007.
Article
in English
| MEDLINE
| ID: mdl-17607794
2.
Org Lett
; 4(4): 619-21, 2002 Feb 21.
Article
in English
| MEDLINE
| ID: mdl-11843606
ABSTRACT
[reaction: see text] A new method to facilitate the separation of diastereomeric syn- and anti-1,3-diols is described. The method relies on the different hydrolysis rates of the corresponding diastereomeric acetonides. Treatment of a dichloromethane solution of syn- and anti-1,3-diol-acetonide with a catalytic amount of diluted aqueous hydrochloric acid leads to the selective cleavage of the anti diastereomer. The resulting anti-1,3-diol can be easily separated from the unchanged syn-1,3-diol-acetonide.