Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Gut ; 69(3): 487-501, 2020 03.
Article in English | MEDLINE | ID: mdl-31189655

ABSTRACT

OBJECTIVE: To investigate whether milk polar lipids (PL) impact human intestinal lipid absorption, metabolism, microbiota and associated markers of cardiometabolic health. DESIGN: A double-blind, randomised controlled 4-week study involving 58 postmenopausal women was used to assess the chronic effects of milk PL consumption (0, 3 or 5 g-PL/day) on lipid metabolism and gut microbiota. The acute effects of milk PL on intestinal absorption and metabolism of cholesterol were assessed in a randomised controlled crossover study using tracers in ileostomy patients. RESULTS: Over 4 weeks, milk PL significantly reduced fasting and postprandial plasma concentrations of cholesterol and surrogate lipid markers of cardiovascular disease risk, including total/high-density lipoprotein-cholesterol and apolipoprotein (Apo)B/ApoA1 ratios. The highest PL dose preferentially induced a decreased number of intestine-derived chylomicron particles. Also, milk PL increased faecal loss of coprostanol, a gut-derived metabolite of cholesterol, but major bacterial populations and faecal short-chain fatty acids were not affected by milk PL, regardless of the dose. Acute ingestion of milk PL by ileostomy patients shows that milk PL decreased cholesterol absorption and increased cholesterol-ileal efflux, which can be explained by the observed co-excretion with milk sphingomyelin in the gut. CONCLUSION: The present data demonstrate for the first time in humans that milk PL can improve the cardiometabolic health by decreasing several lipid cardiovascular markers, notably through a reduced intestinal cholesterol absorption involving specific interactions in the gut, without disturbing the major bacterial phyla of gut microbiota. TRIAL REGISTRATION NUMBER: NCT02099032 and NCT02146339; Results.


Subject(s)
Cardiovascular Diseases/blood , Lipid Metabolism/drug effects , Lipids/pharmacology , Overweight/metabolism , Sphingomyelins/metabolism , Animals , Apolipoprotein A-I/blood , Apolipoprotein B-100/blood , Cholestanol/metabolism , Cholesterol/metabolism , Cholesterol, HDL/blood , Cross-Over Studies , Dietary Supplements , Double-Blind Method , Emulsifying Agents/pharmacology , Feces/chemistry , Female , Gastrointestinal Microbiome/drug effects , Humans , Ileostomy , Intestinal Absorption/drug effects , Lipids/administration & dosage , Lipids/analysis , Middle Aged , Milk/chemistry , Postmenopause , Risk Factors
SELECTION OF CITATIONS
SEARCH DETAIL
...