ABSTRACT
The arterial oxygen and carbon dioxide tensions, pulmonary and systemic haemodynamics and pulmonary shunting and mechanics were measured during the first 30 min after intravenous labetalol administration. Thirty patients, recovering in the intensive care unit after neurosurgical interventions were randomly divided in 2 groups of 15 patients, receiving either labetalol or placebo. In the labetalol treated group the arterial oxygen tension decreased from 553.6 +/- 16.8 to 529.3 +/- 19.8 mmHg 5 min after the injection of labetalol. A concomitant increase in arterial carbon dioxide tension from 40.1 +/- 1.1 to 45.5 +/- 1.3 mmHg was noticed. Pulmonary vascular resistance decreased from 159.6 +/- 14.7 to 116.7 +/- 11.7 dynes.sec.cm-5 and pulmonary shunting increased from 4.8% +/- 1.4% to 8.1% +/- 2.4% 5 min following injection. All these changes were statistically significant for p less than 0.01. After 30 min all values had returned to their initial level. No changes were registered in the control group. As airway resistance appeared not to be affected by the labetalol administration it may be concluded that the observed changes in blood gas data are most likely due to a transient decrease of the pulmonary vascular resistance with a concomitant increase in pulmonary shunting.
Subject(s)
Blood Gas Analysis , Labetalol/pharmacology , Pulmonary Circulation/drug effects , Adult , Craniocerebral Trauma/drug therapy , Hemodynamics/drug effects , Humans , Labetalol/therapeutic use , Lung Compliance/drug effects , Middle Aged , Pulmonary Wedge Pressure/drug effects , Vascular Resistance/drug effectsABSTRACT
The use of computers in the practice of anesthesiology appears to be very promising--therefore the time has come to reflect on ways to utilize the possibilities of computers in this field. The anesthesiologist is faced with an existing "medical information science" and system developments and must now address these questions: How do computers fit in these systems? What is the kind of support and help one can expect from the use of computers? Next one attempts to define the needs for computer support, taking into account the specific working conditions of various anesthesia teams. A description is made of how a system for medical information is automatized--and by way of an example--how such a computer system for anesthesiologists is linked to a larger regional facility. Advantages and disadvantages of such a system are discussed.
