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1.
J Am Acad Audiol ; 14(9): 518-24, 2003 Nov.
Article in English | MEDLINE | ID: mdl-14708840

ABSTRACT

The Hearing-in-Noise Test (HINT) is able to measure the benefit to speech intelligibility in noise conferred when the noise masker is displaced 90 degrees in eccentricity from a speech source located at zero degrees azimuth. Both psychoacoustic and neurophysiological data suggest that the perceptual benefit of the 90-degree azimuth separation would be greatest if the speech and noise were presented in different acoustic hemifields, and would be smallest if the two sources were in the same acoustic hemifield. The present study tested this hypothesis directly in ten normal-hearing adult listeners. Using the HINT stimuli, we confirmed the hypothesis. Release from masking scores averaged 8.61 dB for "between-hemifield" conditions, 6.05 dB for HINT conditions, and 1.27 dB for "within-hemifield" conditions, even though all stimulus configurations retained a 90-degree angular separation of speech and noise. These data indicate that absolute separation of speech and noise alone is insufficient to guarantee a significant release from masking, and they suggest that what matters is the location of the stimulus elements relative to the left and right spatial perceptual channels.


Subject(s)
Hearing/physiology , Noise/adverse effects , Perceptual Masking/physiology , Adult , Analysis of Variance , Female , Humans , Male , Speech Intelligibility , Speech Reception Threshold Test/methods
2.
Hear Res ; 167(1-2): 192-205, 2002 May.
Article in English | MEDLINE | ID: mdl-12117542

ABSTRACT

Historically, central auditory responses have been studied for their sensitivity to various parameters of tone and noise burst stimulation, with response rate plotted as a function of the stimulus variable. The responses themselves are often quite brief, and locked in time to stimulus onset. In the stimulus amplitude domain, it has recently become clear that these responses are actually driven by properties of the stimulus' onset transient, and this has had important implications for how we interpret responses to manipulations of tone (or noise) burst plateau level. That finding was important in its own right, but a more general scrutiny of the available neurophysiological and psychophysical evidence reveals that there is a significant asymmetry in the neurophysiological and perceptual processing of stimulus onsets and offsets: sound onsets have a more elaborate neurophysiological representation, and receive a greater perceptual weighting. Hypotheses about origins of the asymmetries, derived independently from psychophysics and from neurophysiology, have in common a response threshold mechanism which adaptively tracks the ongoing level of stimulation.


Subject(s)
Auditory Cortex/physiology , Auditory Perception/physiology , Acoustic Stimulation , Adaptation, Physiological , Animals , Auditory Pathways/physiology , Auditory Threshold/physiology , Humans , Time Factors
3.
J Neurosci Methods ; 105(2): 133-41, 2001 Feb 15.
Article in English | MEDLINE | ID: mdl-11275270

ABSTRACT

Microdialysis is a useful tool for administering drugs into localized regions of brain tissue, but the diffusion of drugs from the probe has not been systematically examined. Lidocaine (10%) and tetrodotoxin (TTX, 10 microM), drugs typically used in neural inactivation studies, were infused through a microdialysis probe into raccoon somatosensory cortex while evoked responses were recorded at four electrodes equally spaced 0.5--2.0 mm from the probe. The decreases in evoked response amplitude as a function of time and distance from the probe were used as functional measures to describe the time course and spread of the drugs. TTX inactivated distant sites more quickly and to a greater extent than lidocaine. Responses recovered within approximately 40 min after termination of lidocaine, but did not recover for at least 2 h after TTX. Based on these measurements, we estimated that, at the concentrations used, lidocaine has a maximal spread of 2.1 mm, while TTX could spread as far as 4.8 mm from the microdialysis probe. However, in terms of significant inactivation of neuronal activity, lidocaine and TTX have an effective spread of 1 and 2 mm, respectively.


Subject(s)
Anesthetics, Local/pharmacokinetics , Drug Delivery Systems/methods , Lidocaine/pharmacokinetics , Microdialysis , Somatosensory Cortex/drug effects , Tetrodotoxin/pharmacology , Animals , Axons/drug effects , Axons/metabolism , Drug Delivery Systems/instrumentation , Evoked Potentials, Somatosensory/drug effects , Evoked Potentials, Somatosensory/physiology , Female , Male , Raccoons/anatomy & histology , Raccoons/physiology , Somatosensory Cortex/physiology , Time Factors
4.
J Acoust Soc Am ; 106(4 Pt 1): 1948-55, 1999 Oct.
Article in English | MEDLINE | ID: mdl-10530019

ABSTRACT

Human sound localization is acute for frontal locations, but relatively poor in the lateral hemifields. Previous studies in man have not, however, provided evidence on the tuning of the perceptual channels for auditory space that subserve this pattern of acuity. The spatial tuning of perceptual channels used in human azimuthal sound localization was determined using a between-channel auditory temporal gap detection paradigm. In this paradigm, gap thresholds are low when the markers bounding the silent period (gap) activate the same perceptual channel but are elevated when the two markers activate different channels. To determine the tuning of spatial channels, gap thresholds were obtained in an anechoic room with white noise markers coming from each combination of 12 leading marker locations and 18 trailing marker locations throughout the full 360 degrees of azimuth in the horizontal plane through the interaural axis. Gap thresholds remained low (2-4 ms) for all combinations of leading and trailing markers between 30 degrees and 150 degrees in both lateral hemifields. When the leading marker was located deep in one hemifield, and the trailing marker was in the opposite hemifield, gap thresholds rose to 8-16 ms. For leading marker locations at 30 degrees from the midline, gap thresholds were low for all trailing marker locations in the ipsilateral hemifield and locations near the midline in the contralateral hemifield, and were elevated (6-8 ms) only near the contralateral pole. Finally, for leading marker locations at 0 degree or 180 degrees, gap thresholds were low for any trailing location within 30 degrees of the midline at the front or back, and thresholds were elevated for trailing locations at the lateral poles. These data are accountable in terms of two broadly tuned perceptual channels, occupying the left and right auditory hemifields, respectively, each extending 30 degrees across the midline. These channels have widths and locations similar to the spatial receptive fields previously described for central auditory neurons in animals. The data suggest a model of spatial acuity based on the rates of activation of two spatially overlapping channels, rather than the selective activation of members of a large population of finely tuned channels.


Subject(s)
Auditory Perception/physiology , Sound Localization/physiology , Adult , Female , Humans , Male , Sensation/physiology
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