ABSTRACT
The present article was designed to report the results of the analysis of the cases of traumatic and spontaneous ruptures of the organs affected by the tumours based on the original observations and the literature data. It is shown that the probability of the tumour rupture depends on its histological type, localization, the size, and the distance from the capsule of the affected organ, the degree of involvement of the major blood vessels, the severity of the necrotic changes, the presence of cysts in the neoplasm, and the regimens of radio- and chemotherapy. Moreover, the rupture can be facilitated by anticoagulation therapy, intake or oral contraceptives, pregnancy, concomitant diseases, alcoholic intoxication, splenomegaly, and hypocoagulation resulting from dissemination of the neoplastic process or the metastatic lesions of the liver. Even a minimal injury to the skin can provoke the tumour rupture associated with the fatal hemorrhage. A delayed rupture within a few hours or days is possible.
Subject(s)
Hemorrhage , Neoplasms/complications , Risk Assessment/methods , Rupture, Spontaneous/diagnosis , Rupture/diagnosis , Cause of Death , Forensic Medicine , Hemorrhage/etiology , Hemorrhage/mortality , Humans , Neoplasms/classification , Neoplasms/pathology , Risk Factors , Rupture/etiology , Rupture, Spontaneous/etiologyABSTRACT
The article presents a review of references on causes of sudden death of persons suffering from oncological diseases. The paper describes the main mechanisms of sudden death of persons with cancer who are subjected to forensic-medical research. Data on the structure of sudden death for the last 10 years are demonstrated. The authors have identified the increase of a number of sudden deaths in the group with oncological pathology 2. 2 times more in comparison with 2005. There are showed peculiarities of forensic-medical diagnostics of reasons of sudden death in cancer.
Subject(s)
Death, Sudden , Forensic Pathology , Neoplasms/mortality , Autopsy , Cause of Death , Female , Humans , Male , Neoplasms/physiopathologySubject(s)
Liver Cirrhosis/diagnosis , Liver Neoplasms/diagnosis , Liver/pathology , Diagnosis, Differential , False Negative Reactions , Humans , Indium Radioisotopes , Liver/diagnostic imaging , Liver Cirrhosis/diagnostic imaging , Liver Neoplasms/diagnostic imaging , Organotechnetium Compounds , Phytic Acid , Radionuclide Imaging , UltrasonographyABSTRACT
Biochemical markers of gene systems Alb, Tf, Gc, Hp, GLO1, PGM1, EsD, AcP were analysed in the native population of Evenc national region. It is shown that native population of Central Siberia, in spite of its mongoloid racial type, posseses the complex of gene frequencies for protein loci studied which is not typical for mongoloids. The complex may be called "central-siberian" and its origin may be connected with the process of adaptation to environment of the Central Siberian geographical region. The system of gene markers analysed may be considered as a sensitive one in the studies of processes of gene adaptation to the local environmental factors and, in this connection, being perspective in these studies among native population of Siberia.
Subject(s)
Blood Proteins/genetics , Ethnicity , Genes , Genetics, Population , Animals , Breeding , Gene Frequency , Heterozygote , Humans , Male , Phenotype , Reindeer , SiberiaABSTRACT
Population-genetic investigation was carried out in the regions endemic for Viljuisk encephalomyelitis (VE). The following indices were estimated: the relationship coefficient, the inbreeding coefficient, the intensity of migration, genetic structure of the population. The aim of the investigation was to explain causes of intrapopulational and, in some cases, of intragenus accumulation of the VE patients. No evidence of isolation or increased inbreeding were found in highly affected populations. The genetic structure of a group of VE patients tested for 9 polymorphic systems did not reveal any deviation from the control group. Several VE cases in healthy populations occured in some years after the immigration of a VE patient. These data confirm the hypothesis that VE is transmitted from a VE patient to healthy persons. Among these persons fall ill those who have a hereditary determined increased sensitivity to VE which results in intrapopulation and intragenus accumulation of VE cases.