ABSTRACT
The discovery of 5 subtypes of dopamine receptors revealed their important role in development of arterial hypertension and obesity. Reduce of their functional activity or number with age conduces to the increase of tone of the sympathetic nervous system, dyspoiesis of leptin, hyperphagia, development of obesity and arterial hypertension. Prescription of dopamine agonists conduces to reduction of in, normalization of leptin, diminishing of appetite and body mass, decrease of blood pressure. Combination of arterial hypertension and obesity is recommended to determine dopamine excretion and to appoint dopamine agonists at level of < 600 nmol/24 hours.
Subject(s)
Bromocriptine/therapeutic use , Dopamine Agonists/therapeutic use , Hypertension/metabolism , Obesity/metabolism , Receptors, Dopamine/metabolism , Adult , Aged , Appetite/drug effects , Arterial Pressure/drug effects , Body Weight/drug effects , Bromocriptine/pharmacology , Dopamine/blood , Dopamine/urine , Dopamine Agonists/pharmacology , Female , Humans , Hypertension/complications , Hypertension/drug therapy , Leptin/blood , Male , Middle Aged , Norepinephrine/blood , Obesity/complications , Obesity/drug therapy , Sympathetic Nervous System/drug effects , Sympathetic Nervous System/metabolismABSTRACT
By UV spectroscopic data for anhydrous DMSO solutions and ab initio HF/6-31G** calculations in vacuum it was shown for the first time that deprotonated amino acid carboxylic group is able to change tautomeric state of a nucleotide base, exactly to convert the N9H ground-state prototropic tautomer of adenine into the N7H and N1H rare ones.
