[The effect of the acetylation phenotype on the course severity and outcome of acute viral hepatitis B]. / Vliianie fenotipa atsetilirovaniia na tiazhest' techeniia i iskhody ostrogo virusnogo gepatita B.

Acetylation phenotype was studied in 70 inpatients with acute viral hepatitis B. Of them, 51 had fast and 19 slow acetylation. Fast-type acetylation was associated with mild-severe form of hepatitis B, while slow-type acetylation--with recurrences and aggravations, severe form of hepatitis. The duration of HB antigenemia in the slow-type group was twice as long as in the fast-type group. Two patients, "slow acetylators", suffered from hepatitis B in the mild-severe form, later on chronic active hepatitis (CAH) developed. In "fast" acetylators the development of CAH was not observed. Thus, determination of phenotype by acetylation may be used for prognosis of acute viral hepatitis severity as well as for identification of high-risk groups and planning policy of follow-up.

[Evaluation of the immunological reactivity and hormonal profile in patients with breast cancer]. / Otsenka immunologicheskoui reaktivnosti i gormonal'nogo fona u bol'nykh rakom molochnoi zhelezy.

Excretion of 17-HOCS and estrogens as well as the levels of E-RFC and time-delayed DNCB and tuberculin (PPD) contact sensitization reaction were studied in 136 breast cancer patients. A decrease in immunological response in reproductive and menopausal patients was matched by the development of relative hyperestrogenism and elevation of 17-HOCS excretion in the former group and a rise in 17-HOCS excretion only in the latter.

[Use of hormone loading tests for assessing the source of hyperestrogenism and the functional state of the ovaries in breast cancer patients in menopause]. / Primenenie gormonal'nykh nagruzochnykh prob dlia otsenki istochnika giperéstrogenii i funktsional'nogo sostoianiia iaichnikov u bol'nykh rakom molochnoi zhelezy v menopauze.

The source of hyperestrogenia was ascertained in 12 patients by dexametasone-infecundin test, and the ovarian hormonal activity in 5 patients by dexametasone-choriogonin test. The source of hyperestrogenia was found to be the adrenal glands in 50%, ovaries--in 30% and the adrenal together with ovaries--in 20%. Ovarian hormonal activity was retained in 3 of 5 patients under examination. The response to the test concerned was changed in two of them. It is felt that application of hormonal stress tests will make it possible to get detailed indications to castration in menopausal patients with breast cancer.

[Hormonal correlations in hyperplasia of the breasts in women with ovulatory cycles]. / Gormonal'nye sootnosheniia pri giperplaziiakh molochnykh zhelez u zhenshchin s ovuliatornymi tsiklami

An excretion of the follicle-stimulating hormone (FSH), estrogens, pregnandiol, 17-KS, vaginal cytology were studied in 22 patients with dyshormonal hyperplasias of mammary glands and in 12 healthy females with ovulatory cycles. The age of patients under study ranged from 20 to 49 years. The patients showed a higher level of excretion of FSH, estriol, pregnandiol and a lower level of 17-KS excretion than healthy persons.