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1.
Neural Regen Res ; 16(5): 805-812, 2021 May.
Article in English | MEDLINE | ID: mdl-33229713

ABSTRACT

A growing body of evidence has suggested that the imbalance of epigenetic markers and oxidative stress appears to be involved in the pathophysiology and progression of stroke. Thus, strategies that modulate these biomarkers might be considered targets for neuroprotection and novel therapeutic opportunities for these patients. Physical exercise has been reported to induce changes in these epigenetic markers and improve clinical outcomes in different populations. However, little is reported on this in post-stroke patients. The purpose of this study was to investigate the effect of a single exercise session with WalkAide functional electrical stimulation (FES) on cognitive performance, clinical functional parameters, oxidative stress and epigenetic modulation in post-stroke individuals. In this crossover design study, 12 post-stroke individuals aged 54-72 years of either sexes were included and subjected to a single session of exercise (45 minutes) without WalkAide functional electrical stimulation (EXE alone group), followed by another single session of exercise (45 minutes) with WalkAide functional electrical stimulation (EXE + FES group). The clinical functional outcome measures, cognitive performance and blood collections for biomarker measurements were assessed pre- and post-intervention. After intervention, higher Berg Balance Scale scores were obtained in the EXE + FES group than in the EXE alone group. There was no significant difference in the Timed Up and Go test results post-intervention between EXE alone and EXE + FES groups. After intervention, a better cognitive performance was found in both groups compared with before the intervention. After intervention, the Timed Up and Go test scores were higher in the EXE + FES group than in the EXE alone group. In addition, the intervention induced lower levels of lipid peroxidation. After intervention, carbonyl level was lower, superoxide dismutase activity and superoxide dismutase/catalase activity ratio were higher in the EXE + FES group, compared with the EXE group alone. In each group, both histone deacetylase (HDAC2) and histone acetyltransferase activities were increased after intervention compared with before the intervention. These findings suggest that a single exercise session with WalkAide FES is more effective on balance ability and cognitive performance compared with conventional exercise alone in post-stroke patients. This is likely to be related to the regulation of oxidative stress markers. The present study was approved by the Research Ethics Committee of the Methodist University Center-IPA (approval No. 2.423.376) on December 7, 2017 and registered in the Brazilian Registry of Clinical Trials-ReBEC (RBR-9phj2q) on February 11, 2019.

2.
Fisioter. Pesqui. (Online) ; 24(3): 238-244, jul.-set. 2017. tab
Article in Portuguese | LILACS | ID: biblio-892124

ABSTRACT

RESUMO O crescimento da população idosa exige reorganização política, econômica e social, em especial na área da saúde, devido ao impacto sobre esta. A avaliação da Probabilidade de Internação Hospitalar (PIH) é usada como indicador da condição de saúde do idoso. Entretanto, variáveis de capacidade física (CF) ainda não foram associadas com a PIH. Analisou-se a associação entre CF e a PIH de idosos. O estudo realizado foi epidemiológico, transversal e analítico. A seleção da amostra ocorreu de forma aleatória em uma das Equipes de Saúde da Família no bairro Passo d'Areia, no município de Porto Alegre, sendo avaliados 317 idosos com idade ≥ 65 anos. A CF foi avaliada por testes de força de membros superiores e inferiores, flexibilidade e equilíbrio. A PIH foi avaliada pelo instrumento de triagem rápida de Boult. Para análise estatística, a PIH foi ajustada em dois grupos: baixa-média e média alta-alta (MAA) e realizada a análise multivariada de regressão de Poisson. O nível de significância adotado foi de p ≤ 0,05. Nos resultados encontrados, as variáveis físicas que permaneceram associadas à PIH-MAA foram a força de membros inferiores (RP = 1,78; IC 95% = 1,04 - 3,04) e flexibilidade (RP = 2,13; IC 95% = 1,28 - 3,56). Houve associação negativa entre os baixos níveis de força de membro inferior e de flexibilidade com PIH-MAA. A prevalência da PIH-MAA entre indivíduos com força alterada para membros inferiores foi 78% maior em relação àqueles com força normal e 113% entre aqueles com alteração de flexibilidade.


RESUMEN El crecimiento de la población anciana exige reorganización política, económica y social, en especial en el área de la salud, debido al impacto sobre ésta. La evaluación de la Probabilidad de Ingreso Hospitalario (PIH) es usada como indicador de la condición de salud del anciano. Mientras tanto, variables de la capacidad física (CF) todavía no fueron asociadas con la PIH. Se analizó la asociación entre la CF y la PIH de ancianos. El estudio realizado fue epidemiológico, transversal y analítico. La selección de la muestra ocurrió de manera aleatoria en uno de los Equipos de Salud de la Familia en el barrio Passo d'Areia, en el municipio de Porto Alegre, siendo evaluados 317 ancianos con edad ≥ 65 años. La CF fue evaluada por pruebas de fuerza de miembros superiores e inferiores, flexibilidad y equilibrio. La PIH fue evaluada por el instrumento de triaje rápido de Boult. Para el análisis estadístico, la PIH fue ajustada en dos grupos: baja-mediana y mediana alta-alta (MAA) y realizado el análisis multivariado de regresión de Poisson. El nivel de significancia adoptado fue de p ≤ 0,05. En los resultados encontrados, las variables físicas que permanecieron asociados a la PIH-MAA fueron la fuerza de miembros inferiores (RP = 1,78; IC el 95% = 1,04 - 3,04) y la -flexibilidad (RP = 2,13; IC el 95% = 1,28 - 3,56). Hubo asociación negativa entre los bajos niveles de fuerza de miembro inferior y de flexibilidad con la PIH-MAA. La prevalencia de la PIH-MAA entre los individuos con la fuerza alterada para los miembros inferiores fue un 78% más grande en relación a los con la fuerza normal y un 113% entre los con alteración de flexibilidad.


ABSTRACT The growth of older population requires political, economic and social rearrangement, particularly in health, considering its impact on this matter. The assessment of Likelihood of Hospitalization (LOH) is used as an indicator for the health condition of older adults. However, variables of physical capacity (PC) have not yet been associated with LOH. Thus, the association between PC and LOH was analyzed. This study was epidemiological, cross-sectional, and analytical. The sample was randomly selected from one of the Family Health Teams in Passo d'Areia neighborhood, municipality of Porto Alegre. 317 older adults aged ³65 years were evaluated. PC was evaluated by tests of strength, flexibility, and balance on upper and lower limbs. LOH was evaluated with the Boult rapid screening instrument. For the statistical analysis, LOH has been adjusted in two groups: low-medium and medium high-high (MHH), and the Poisson multivariate regression analysis was used. The adopted significance level was p≤0.05. Among the results found, the physical variables that stayed attached to the LOH-MHH were the strength of lower limbs (PR=1.78; 95%CI=1.04 - 3.04) and flexibility (PR=2.13; 95%CI=1.28 - 3.56). There was a negative association between low levels of lower limb strength and flexibility with LOH-MHH. The prevalence of LOH-MHH among individuals with altered strength for the lower limbs was 78% greater when compared with those with normal strength, and it was 113% greater for those with altered flexibility.

3.
Estud. interdiscip. envelhec ; 20(1): 189-203, abr. 2015. tab
Article in Portuguese | Index Psychology - journals | ID: psi-70443

ABSTRACT

O envelhecimento populacional brasileiro é uma realidade e provoca novas demandas na área da saúde do idoso. Nesse contexto, saúde não significa mais a ausência de doenças e, sim, a manutenção da capacidade funcional. Objetivos: verificar o grau de independência funcional de idosos residentes em uma área adscrita da vila do IAPI (Instituto de Assistência e Previdência dos Industriários) em Porto Alegre e correlacionar o grau de independência funcional com variáveis socioeconômicas e de saúde. Métodos: trata-se de um estudo transversal de base populacional, no qual os dados foram obtidos através de visitas domiciliares. A capacidade funcional foi avaliada com a Escala de Katz, o Índice de Lawton e o nível de atividade física pelo IPAQ versão 6. Os dados foram analisados pelo SPSS (Statistical Package for the Social Sciences) versão 17.0 por meio de análises bivariada e multivariada pela Regressão de Poisson hierárquica. Resultados: foram entrevistados 401 idosos e os fatores associados à independência funcional foram: ocupação (RP = 1,18), idade (RP = 0,97), ser ativo ou muito ativo fisicamente (IPAQ) (RP = 6,86) e participar de grupos de apoio (RP = 1,21). A depressão associou-se negativamente com a independência funcional (RP = 0,77). Conclusões: os resultados permitiram identificar o comportamento da capacidade funcional entre os idosos avaliados, sendo a maioria destes classificados como independentes. Faz-se importante salientar que a manutenção da capacidade funcional deve ser estimulada através de políticas públicas de promoção da saúde física e mental, redes de apoio social e participação ativa nos vários segmentos da sociedade. (AU)


The aging of the Brazilian population is a reality, and it causes new demands when the subject is elderly health. In this context, health is not anymore the absence of diseases, but the maintenance of the functional capacity. Objectives: this paper aims to verify the level of functional independence of the elderly at an enrolled area of the village of IAPI, in Porto Alegre, and correlate the level of functional independence with socioeconomic and health variables. Methods: this is a population-based cross-sectional study in which the data were obtained through home visits. The functional capacity was valued with Katz and Lawton scales, and the level of physical activity was valued through IPAQ – version 6. The data were analyzed by SPSS (Sta and multivariate analyzes by hierarchical Poison Regression. Results: 401 people were interviewed, and the factors associated to functional independence were: occupation (RP = 1,18), age (RP = 0,97), be physically active or very active (IPAQ) (RP = 6,86) and participate of support groups (RP = 1,21). Depression was associated negatively with functional independence (RP = 0,77). Conclusions: results allowed the identification of the behavior of functional capacity among elderly patients, most of these being classified as independent. It is important to note that maintenance functional capacity should be encouraged through physical and mental health public policies, social support networks, and active participation in the various segments of society. (AU)


Subject(s)
Humans , Male , Female , Aged , Aged, 80 and over , Activities of Daily Living/psychology , Dependency, Psychological , Aging/psychology , Cross-Sectional Studies
4.
Estud. interdiscip. envelhec ; 20(1): 189-203, abr. 2015. tab
Article in Portuguese | LILACS | ID: biblio-868911

ABSTRACT

O envelhecimento populacional brasileiro é uma realidade e provoca novas demandas na área da saúde do idoso. Nesse contexto, saúde não significa mais a ausência de doenças e, sim, a manutenção da capacidade funcional. Objetivos: verificar o grau de independência funcional de idosos residentes em uma área adscrita da vila do IAPI (Instituto de Assistência e Previdência dos Industriários) em Porto Alegre e correlacionar o grau de independência funcional com variáveis socioeconômicas e de saúde. Métodos: trata-se de um estudo transversal de base populacional, no qual os dados foram obtidos através de visitas domiciliares. A capacidade funcional foi avaliada com a Escala de Katz, o Índice de Lawton e o nível de atividade física pelo IPAQ versão 6. Os dados foram analisados pelo SPSS (Statistical Package for the Social Sciences) versão 17.0 por meio de análises bivariada e multivariada pela Regressão de Poisson hierárquica. Resultados: foram entrevistados 401 idosos e os fatores associados à independência funcional foram: ocupação (RP = 1,18), idade (RP = 0,97), ser ativo ou muito ativo fisicamente (IPAQ) (RP = 6,86) e participar de grupos de apoio (RP = 1,21). A depressão associou-se negativamente com a independência funcional (RP = 0,77). Conclusões: os resultados permitiram identificar o comportamento da capacidade funcional entre os idosos avaliados, sendo a maioria destes classificados como independentes. Faz-se importante salientar que a manutenção da capacidade funcional deve ser estimulada através de políticas públicas de promoção da saúde física e mental, redes de apoio social e participação ativa nos vários segmentos da sociedade.


The aging of the Brazilian population is a reality, and it causes new demands when the subject is elderly health. In this context, health is not anymore the absence of diseases, but the maintenance of the functional capacity. Objectives: this paper aims to verify the level of functional independence of the elderly at an enrolled area of the village of IAPI, in Porto Alegre, and correlate the level of functional independence with socioeconomic and health variables. Methods: this is a population-based cross-sectional study in which the data were obtained through home visits. The functional capacity was valued with Katz and Lawton scales, and the level of physical activity was valued through IPAQ – version 6. The data were analyzed by SPSS (Sta and multivariate analyzes by hierarchical Poison Regression. Results: 401 people were interviewed, and the factors associated to functional independence were: occupation (RP = 1,18), age (RP = 0,97), be physically active or very active (IPAQ) (RP = 6,86) and participate of support groups (RP = 1,21). Depression was associated negatively with functional independence (RP = 0,77). Conclusions: results allowed the identification of the behavior of functional capacity among elderly patients, most of these being classified as independent. It is important to note that maintenance functional capacity should be encouraged through physical and mental health public policies, social support networks, and active participation in the various segments of society.


Subject(s)
Humans , Male , Female , Aged , Aged, 80 and over , Activities of Daily Living/psychology , Dependency, Psychological , Aging/psychology , Cross-Sectional Studies
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