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Bioorg Med Chem Lett
; 11(14): 1829-32, 2001 Jul 23.
Article
in English
| MEDLINE
| ID: mdl-11459641
ABSTRACT
Oxazolidinone antibacterial agents, where the N-substituted piperazinyl group of eperezolid was replaced with a N-substituted piperidinyloxy moiety, were synthesized and shown to be active against a variety of resistant and susceptible Gram-positive organisms. The effect of ring size, positional isomerism, and fluorine substitution on antibacterial activity was examined.