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Dig Dis Sci ; 53(4): 905-11, 2008 Apr.
Article in English | MEDLINE | ID: mdl-18270827

ABSTRACT

BACKGROUND: The purpose of this study was to determine whether a high-resolution solid-state catheter system could detect regional pressure changes within the antrum and pylorus in response to CCK-octapeptide. METHODS: Subjects received a 30 min infusion of CCK-octapeptide at either 0.02 or 0.06 microg kg(-1) h(-1). RESULTS: Five males and two females were studied. Mean antral pressure during phase I MMC increased from 5.3 +/- 2.1 to 9.9 +/- 2.4 mmHg (P = 0.028) after infusion. At the pylorus, only the 0.06 microg kg(-1) h(-1) dose increased tonic pressure (8.8 +/- 1.4 to 17.6 +/- 2.0 mmHg; P = 0.01) as compared with the 0.02 microg kg(-1) h(-1) dose (4.7 +/- 0.7 to 7.3 +/- 0.4 mmHg; P = NS). The peak pressure of pyloric phasic pressure waves was 153 +/- 28.4 mmHg and their frequency was 4.9 +/- 1.1 contractions min(-1). CONCLUSIONS: CCK-octapeptide elicits both tonic and phasic activity of the pyloric sphincter. The contractile response to a dose of 0.06 mug kg(-1) h(-1) is greater than the response to 0.02 mug kg(-1) h(-1).


Subject(s)
Manometry/instrumentation , Myoelectric Complex, Migrating/drug effects , Pyloric Antrum/drug effects , Pylorus/drug effects , Sincalide/pharmacology , Adult , Catheterization , Dose-Response Relationship, Drug , Equipment Design , Female , Gastric Emptying/drug effects , Humans , Infusions, Intravenous , Male , Pyloric Antrum/physiopathology , Pylorus/physiopathology , Sincalide/administration & dosage , Transducers
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