ABSTRACT
Taking into consideration the nanodimension of functional components of living cells, the application of nanotechnology in the biomedical purposes is currently an urgent task. One of these directions is the use of aluminum nanoparticles for molecular diagnostics, targeted delivery of drugs, the development of new pharmaceuticals. The action of aluminum chloride on the regulatory mechanisms of smooth and skeletal muscle contraction and also the effect of aluminum ions on the ATPase activity and superprecipitation of actomyosin of different types of muscles is discussed.
Subject(s)
Aluminum Compounds/pharmacology , Aluminum , Biomedical Technology/methods , Chlorides/pharmacology , Nanomedicine/methods , Adenosine Triphosphate/metabolism , Aluminum/chemistry , Aluminum/pharmacology , Aluminum Chloride , Animals , Drug Carriers/chemistry , Humans , Muscle Contraction/drug effects , Muscle, Skeletal/drug effects , Muscle, Skeletal/metabolismABSTRACT
The effect of C60 fullerene aqueous colloid solution (C60FAS) on viscoelastic properties of human erythrocytes membrane has been studied. It was established that the effect of C60FAS on erythrocytes depends on the medium osmolality and concentration of C60 fullerene in it. In particular, in isotonic solution (0,15 mol/l NaCl) adding C60 fullerene in concentrations from 0,7 to 28 µmol/l did not cause the hemolytic damage of cells. In hypotonic medium when introducing C60 fullerene (7 µmol/l concentration) at the beginning of erythrocyte hemolysis its stimulating effect was maximal and when adding C60FAS in 20 s after hemolysis start no this process stimulation is observed. This points to the changes in viscoelastic properties of erythrocyte membranes even during the first seconds of its interaction with C60 fullerene.
Subject(s)
Erythrocyte Membrane/drug effects , Fullerenes/pharmacology , Colloids , Elasticity , Erythrocyte Membrane/chemistry , Hemolysis/drug effects , Humans , Osmotic Fragility/drug effects , Sodium Chloride/pharmacology , Time Factors , ViscosityABSTRACT
The influence of pH medium on ATP-ase activity of skeletal muscles myosin has been investigated. The mathematical simulation, which reflects the ATP-hydrolase biochemical reactions after pH medium changes in the muscular fiber was also carried out.
