[Functional reserves of humans in North condition and its providing of fat-soluble vitamins].

It was been examined 810 healthy peoples inhabited in Russian European North. It was been shown that more than 35% of examined person from different group have lowered serum level of retinol and alpha-tocopherol. Described that alpha-tocopherol deficits occur more often and proposed that it cased as a result of free radical oxidation typical for North inhabitances.

[Polymorphism of the apolipoprotein E gene (APOE) in the populations of Russia and neighboring countries].

Allele and genotype frequencies for the locus encoding apolipoprotein E, involved in the regulation of lipid metabolism (APOE), were evaluated in 16 populations representing 12 ethnic groups (a total of 1103 subjects) from Russia and neighboring countries. In the populations examined, the frequencies of allele epsilon4, which is the risk factor of Alzheimer's disease and coronary heart disease, varied from less than 5 to more than 20%, while the variation of the major epsilon3 allele in these populations ranged from less than 75 to 95%. The frequencies of alleles epsilon3 and epsilon4 were 0.714 and 0.205 in Saami, 0.734 and 0.149 in Maris, 0.841 and 0.122 in Evenks, 0.788 and 0.163 in Buryats, 0.764 and 0.202 in Chukchi, 0.875 and 0.075 in Iranians, 0.956 and 0.044 in mountain-dwellers of the Pamirs, 0.771 and 0.094 in Ukrainians, and 0.795 and 0.091 in Belarussians, respectively. In Russians from different regions of the country, the frequencies of these alleles were 0.728 and 0.139 (Kostroma), 0.795 and 0.105 (Moscow), 0.857 and 0.092 (Rostov-on-Don), and 0.824 and 0.083 (Krasnodar), respectively. The latitudinal distribution of the APOE epsilon3 and epsilon4 allele frequencies in the populations examined was comparable to the frequency distribution pattern of these alleles in other populations of Eurasia.

[Uric acid, apo-E and apo-C3 correlation in normo- and hyperlipidemia].

AIM: To investigate correlations between the levels of uric acid and apo-E in patients with normo- and hyperlipidemia. MATERIAL AND METHODS: Serum lipids, apolipoprotein spectrum and uric acid levels were measured with Chronolab (Switzerland) kits in 78 patients: 58 with normolipidemia and 25 patients with hyperlipidemia of type IIa and IIb. RESULTS: Significantly higher levels of apo-E were registered in patients with hyperlipidemia than in patients with normolipidemia, but there were no differences by content of uric acid. A comparative correlation analysis detected a significant correlation between uric acid levels and apo-E in both groups but in normolipidemic patients the correlation was positive while in hyperlipidemic patients it was negative. CONCLUSION: Hyperlipidemia provokes inversion of correlation between the levels of uric acid, apo-E and apo-C3. A rise of apo-C3 may serve an adaptive mechanism of inhibition of apo-E induced hyperlipidemia.