ABSTRACT
Bridged tetracyclic tetrahydroquinoline is synthesized by a novel one-pot three component condensation of an ortho-amino cinnamate, alpha-isocyano acetamide and an aldehyde.
ABSTRACT
Synthesis of fully protected actinoidic acid derivative 3 and selectively protected biaryl bisamino acid 4, intermediates for vancomycin total synthesis, are reported.
Subject(s)
Biphenyl Compounds/chemical synthesis , Phenylacetates/chemical synthesis , Vancomycin/chemical synthesis , Biphenyl Compounds/chemistry , Indicators and Reagents , Models, Molecular , Molecular Conformation , Phenylacetates/chemistry , Vancomycin/chemistryABSTRACT
Pterobilin 1 (biliverdin IX gamma), a butterfly bile pigment, is photocyclized into phorcabilin 2 and sarpedobilin 3 by irradiation in visible light. Selective irradiations have now been performed at the absorption maxima of pterobilin 1. The 650-nm radiations are responsible for the observed photocyclizations while the 375-nm radiations lead to decomposition products. These results are discussed in connection with a hypothesis concerning the biological role of pterobilin in butterfly larvae.
