Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Science ; 354(6314): 893-897, 2016 11 18.
Article in English | MEDLINE | ID: mdl-27856909

ABSTRACT

A kinship between cranial and pelvic visceral nerves of vertebrates has been accepted for a century. Accordingly, sacral preganglionic neurons are considered parasympathetic, as are their targets in the pelvic ganglia that prominently control rectal, bladder, and genital functions. Here, we uncover 15 phenotypic and ontogenetic features that distinguish pre- and postganglionic neurons of the cranial parasympathetic outflow from those of the thoracolumbar sympathetic outflow in mice. By every single one, the sacral outflow is indistinguishable from the thoracolumbar outflow. Thus, the parasympathetic nervous system receives input from cranial nerves exclusively and the sympathetic nervous system from spinal nerves, thoracic to sacral inclusively. This simplified, bipartite architecture offers a new framework to understand pelvic neurophysiology as well as development and evolution of the autonomic nervous system.


Subject(s)
Ganglia, Sympathetic/physiology , Neurons/physiology , Sacrum/innervation , Sympathetic Nervous System/physiology , Animals , Ganglia, Sympathetic/cytology , Ganglia, Sympathetic/embryology , Mice , Neurons/metabolism , Nitric Oxide Synthase Type I/metabolism , Parasympathetic Nervous System/anatomy & histology , Parasympathetic Nervous System/embryology , Parasympathetic Nervous System/physiology , Pelvis/anatomy & histology , Pelvis/embryology , Pelvis/innervation , Sacrum/anatomy & histology , Sacrum/embryology , Spinal Nerves/physiology , Sympathetic Nervous System/anatomy & histology , Sympathetic Nervous System/embryology , Thorax/innervation , Transcription, Genetic , Vesicular Acetylcholine Transport Proteins/metabolism
SELECTION OF CITATIONS
SEARCH DETAIL
...