Subject(s)
Botany/history , Expeditions/history , Travel/history , Americas , Argentina , France , History, Modern 1601-ABSTRACT
A case is reported of a bilateral atypical mycobacterial infection, occurring in a 44 year old male with antecedent silicosis. Successful surgical resection was performed after 17 months of failed chemotherapy. The atypical mycobacterium which is unclassified is intermediate between Mycobacterium avium-intracellulare. Mycobacterium terrae complex and Mycobacterium gastri. It has some similarities with the newly described species, Mycobacterium malmöense.
Subject(s)
Lung Diseases/etiology , Mycobacterium Infections, Nontuberculous/microbiology , Mycobacterium Infections/microbiology , Mycobacterium/isolation & purification , Nontuberculous Mycobacteria/isolation & purification , Adult , Humans , MaleABSTRACT
An M. intracellulare, rough strain (serotype 7) has been isolated from sputum of a sixty-year old patients. This patient was a political prisoner in Germany between 1942-1945 and had contracted pulmonary tuberculosis with the cavity in the upper lobe of the right lung. A strain of mycobacterium susceptible to antituberculous drugs was isolated from his sputum in 1973. Since 1979, the isolation of M. Intracellulare has been accompanied by clinical signs of pulmonary mycobacteriosis, i.e. persistence of the cavity in spite of antituberculous treatments reapparition of cough with sputum, general weakness. Intradermo-reaction with specific sensitin gives a strong positive reaction, contrasting with a weak reaction with PPD tuberculin. As the antibiogram of the strain shows a susceptibility to cotrimoxazole and erythromycin, the patient underwent a therapy with the combination sulfamethaxozale-trimethoprime and erythromycin, for 4 months. At the end of this treatment, he seems to have recovered completely. The radiological aspect of the lungs remains unchanged. Although the source of contamination remains unknown, one thinks on the basis of bibliographica data, that it can be found in human beings, or seldom in animals (a pig, a bird) or in nature (a pond).
Subject(s)
Tuberculosis, Pulmonary/microbiology , Animals , Anti-Bacterial Agents/pharmacology , Chickens , Drug Resistance, Microbial , Guinea Pigs , History of Medicine , Humans , Male , Mice , Middle Aged , Mycobacterium Infections, Nontuberculous/microbiology , Nontuberculous Mycobacteria/drug effects , Nontuberculous Mycobacteria/pathogenicity , Nontuberculous Mycobacteria/physiology , Rabbits , Sputum/microbiology , VirulenceSubject(s)
Allergy and Immunology/history , Microbiology/history , Rabies/history , France , History, Modern 1601-ABSTRACT
The 24 strains of Mycobacterium simiae described in this report were isolated from 12 black Africans, 6 from white Europeans, 5 from primates and 1 from a leprosy infected Armadillo. These strains form 3 groups having the similar morphologic and cultural properties as M. intracellulare. Two groups were similar with respect to pigmentation, urease activity and niacin production but differed serologically, the second group being of M. intracellulare serotype 18. The third group was less homogenous and was intermediate to M. simiae and M. intracellulare. Thus M. simiae belong to the M. avium-intracellulare-simiae-scrofulaceum (MAISS) complex. Two cases of well characterized pulmonary disease progressed like M. avium mycobacteriosis.
Subject(s)
Mycobacterium/classification , Animals , Anti-Bacterial Agents/pharmacology , Guinea Pigs , Haplorhini , Humans , Mice , Microbial Sensitivity Tests , Mycobacterium/drug effects , Mycobacterium/metabolism , Mycobacterium/pathogenicity , Mycobacterium avium/classification , Mycobacterium avium/drug effects , Mycobacterium avium/metabolism , Mycobacterium avium/pathogenicity , Rabbits , SerotypingABSTRACT
Nine stains of Mycobacterium ulcerans isolated in Kamerun, in Congo and in France, were compared with six reference strains found in Zaïre, Australia and Mexico and M. intracellulare, M. simiae, M. paratuberculosis. These fiveteen strains constitutets an species whose typical features were: the difficult and slow growth at the optimum temperature of 30 degrees C, the biochemical tests and the sensitivity to rifampin, streptomycin, kanamycin, viomycin, cycloserin and probably capreomycin. In mice inoculated by the intravenous route, M. ulcerans gives ulcerations of external teguments and sometimes, internal lesions.
Subject(s)
Mycobacterium Infections/epidemiology , Skin Ulcer/epidemiology , Anti-Bacterial Agents/pharmacology , Cameroon , Catalase/metabolism , Humans , Microbial Sensitivity Tests , Mycobacterium/drug effects , Mycobacterium/isolation & purification , Mycobacterium/metabolism , Mycobacterium Infections/microbiology , Nitrates/metabolism , Nitrites/metabolism , Peroxidases/metabolismABSTRACT
The action of treatment with 4 p. cent sulphuric acid for 10 minutes, was tested on 13 strains of mycobacteria. Rapidly growing mycobacteria, e.g. M. diernhoferi, M. chelonei M. abscessus, M. Fortuitum, proved much more sensitive than slowly growing mycobacteria, e.g. M. xenopi, M, scrofulacem, M. kansaii, M. avium, M. marinum, BCG, M. tuberculosis and M. Bovis. We observed the persistance of a certain number of viable bacteria in spite of a duration of contact of 120 minutes, Albumin in the culture medium used presented a protective effect together with the high concentration in bacteria.
Subject(s)
Mycobacterium/drug effects , Sulfuric Acids/pharmacology , Albumins/pharmacology , Culture Media , Drug Resistance, Microbial , Mycobacterium/growth & development , Species Specificity , Time FactorsSubject(s)
Mycobacterium/analysis , Tuberculosis, Pulmonary/microbiology , Animals , Anti-Bacterial Agents/pharmacology , Bacteriological Techniques , Culture Media , Female , Guinea Pigs , Hemagglutination Tests , Humans , Immunodiffusion , Male , Mycobacterium/immunology , Mycobacterium/metabolism , Organ Culture Techniques , Rabbits , Rats , Tuberculosis, Pulmonary/etiologySubject(s)
Mycobacterium , Pigmentation , Animals , Anti-Bacterial Agents/pharmacology , Culture Media , Guinea Pigs , Microbial Sensitivity Tests , Mycobacterium/classification , Mycobacterium/drug effects , Mycobacterium/growth & development , Mycobacterium/metabolism , Mycobacterium/pathogenicity , Rabbits , TemperatureABSTRACT
Wax D(P), a peptido-glycolipid found in extracts of Mycobacterium tuberculosis var. hominis, was not found in extracts of three strains of still-grown M. tuberculosis var. bovis (BCG, Marmorek and Dupray). However, extracts from three other bovine strains (Behring, LA and BB) did yield waxes D(P), and these did not differ as to their molar ratios of alanine/glutamic acid/diaminopimelic acid from human waxes D(P).