ABSTRACT
Chromosome studies were performed on a plexiform neurofibroma arising in a probable von Recklinghausen's disease patient, who also showed a de novo constitutional reciprocal translocation, t(1;22)(p32;q11). Banding analysis of the metaphases obtained from two primary cultures in vitro showed the presence of five cytogenetic clones, characterized by different chromosomal rearrangements. In addition to t(1;22), marker chromosomes involved pairs 1, 2, 3, 5, 8, 9, 10, 12, 16, and X. These findings suggest a possible polyclonal evolution in this neurofibroma.
Subject(s)
Neoplasm Recurrence, Local/genetics , Neurofibroma/genetics , Neurofibromatosis 1/genetics , Translocation, Genetic , Adult , Chromosome Banding , Chromosomes, Human, Pair 1 , Chromosomes, Human, Pair 22 , Female , Genetic Markers , Humans , Karyotyping , Neoplasm Recurrence, Local/pathology , Neurofibroma/pathology , Neurofibromatosis 1/pathologySubject(s)
Bone Transplantation , Spinal Fusion , Spinal Osteophytosis/surgery , Adolescent , Adult , Aged , Cervical Vertebrae/diagnostic imaging , Female , Humans , Intervertebral Disc Displacement/diagnostic imaging , Intervertebral Disc Displacement/surgery , Male , Middle Aged , Radiography , Spinal Osteophytosis/diagnostic imaging , Transplantation, HeterologousSubject(s)
Arteritis/chemically induced , Cerebrovascular Disorders/etiology , Contraceptives, Oral, Hormonal/adverse effects , Contraceptives, Oral/adverse effects , Adult , Arteritis/complications , Arteritis/diagnostic imaging , Blood Vessels/drug effects , Contraceptives, Oral, Hormonal/pharmacology , Female , Humans , RadiographyABSTRACT
A cytogenetic study was made in 17 human brain tumors (12 astrocytomas, 4 meningiomas and 1 ependymoma) to know the value of in vitro tissue culture procedures for the chromosomal analysis of said neoplasms. The obtained data were compared with the observation of direct samples of the same tumors in order to differentiate neoplastic and non-neoplastic cells proliferating in vitro. It was shown the validity of the tissue culture technique for the cytogenetic analysis of brain tumors. The most frequent abnormality was hypodiploidy with involvement of number 22 chromosome. Some ependymomas had a triploid set of chromosomes. Gliomas showed abnormalities involving mainly number 1, 2, 7, 11 and 22 chromosomes.
Subject(s)
Astrocytoma/genetics , Brain Neoplasms/genetics , Ependymoma/genetics , Meningeal Neoplasms/genetics , Meningioma/genetics , Humans , KaryotypingABSTRACT
A case of spontaneous carotid-cavernous fistula is presented in a patient suffering from osteogenesis imperfecta tarda type I. The patient was operated on under local anesthesia by intraluminal occlusion of the cavernous carotid artery with a Fogarty catheter, in accordance with Prolo's technique, with total remission except for homolateral loss of vision due to postglaucoma atrophy. the pathogenetic phenomena described in the literature are reviewed, with the suggestion that osteogenesis imperfecta be included with Ehlers-Danlos disease, Marfan's syndrome, and pseudoxanthoma elasticum, as a connective tissue disease with increased weakness of vessel walls that can produce a spontaneous carotid-cavernous fistula. Reports of cases operated on by intraluminal occlusion with various types of balloon-tipped catheters are also reviewed. The good results obtained place this technique among the elective ones for the treatment of carotid-cavernous fistula.