ABSTRACT
INTRODUCTION: Ampullary adenocarcinoma is a rare entity during pregnancy. It accounts for 0.5% of all gastrointestinal malignancies. The best treatment modality for resectable tumors with the best reported outcome is surgical resection in the form of pancreaticoduodenectomy (Whipple procedure). In this case report, we discuss the challenges in the management of ampullary adenocarcinoma in a pregnant patient. CASE PRESENTATION: We report a case of 22 years old pregnant women who presented with vague abdominal pain and jaundice at the 28th week of gestation. Endoscopic retrograde cholangiopancreatography (ERCP) showed a stricture around the ampulla and distal common bile duct (CBD). The CBD was stented and a biopsy was taken. Histopathology revealed: an invasive adenocarcinoma. The patient was managed by elective pancreaticoduodenectomy after induction of vaginal delivery at the 34th week of gestation. CONCLUSION: Diagnosing and managing ampullary adenocarcinoma in pregnant patients in their 3rd trimester is challenging. Yet, a delayed viable delivery followed by a definitive surgery in the form of pancreaticoduodenectomy offers the best outcomes for both the mother & fetus in case of early stage disease.
ABSTRACT
The association of endodermal sinus tumor, known also as yolk sac tumor, of the mediastinum with hemophagocytic syndrome is exceedingly rare with only a few cases on record. We report a 24-year-old male who had a large mediastinal germ cell tumor, proven to be an endodermal sinus tumor on biopsy. The patient developed pancytopenia and coagulopathy related to associated hemophagocytic syndrome, with a fatal outcome. A brief review of the relevant literature is presented as well.
Subject(s)
Endodermal Sinus Tumor/complications , Lymphohistiocytosis, Hemophagocytic/complications , Mediastinal Neoplasms/complications , Bone Marrow/pathology , Endodermal Sinus Tumor/diagnostic imaging , Endodermal Sinus Tumor/pathology , Fatal Outcome , Humans , Lymphohistiocytosis, Hemophagocytic/diagnostic imaging , Lymphohistiocytosis, Hemophagocytic/pathology , Male , Mediastinal Neoplasms/diagnostic imaging , Mediastinal Neoplasms/pathology , Tomography, X-Ray Computed , Young AdultSubject(s)
Cystadenoma, Mucinous/diagnostic imaging , Cystadenoma, Mucinous/surgery , Liver Neoplasms/diagnostic imaging , Liver Neoplasms/surgery , Abdominal Pain/diagnosis , Abdominal Pain/etiology , Adult , Biopsy, Needle , Follow-Up Studies , Hepatectomy/methods , Humans , Immunohistochemistry , Male , Neoplasm Staging , Tomography, X-Ray Computed/methods , Treatment Outcome , Ultrasonography, DopplerABSTRACT
Combined ductal and vascular injuries are awesome complications of pancreatic injury. We report on a 29-year-old male unrestrained driver who sustained a blunt abdominal injury from the steering wheel in a high velocity head-on car collision. He developed a pancreatic fistula, portosplenic venous thrombosis and sinistral portal hypertension as a result of complete duct disruption at the pancreatic neck. We describe a safe surgical strategy of spleen-preserving distal pancreatectomy after failed medical and endoscopic management.
