ABSTRACT
Paclitaxel dosage form on nanoparticles of 200-300 nm based on lactic and glycolic acid copolymer was obtained by the co-precipitation method. The possibility of controlled release of paclitaxel at pH 7.4 for 24 h was studied in vitro. Studies on Jurkat/WT human T-lymphoblastic leukemia cells showed that incorporation of paclitaxel in the nanoparticles led to a 4-fold increase of its cytotoxicity (6.8×10(-6) M) in comparison with paclitaxel solution. The efficiency of compositions containing polysorbate-80 was comparable to that of non-modified nanoparticles containing paclitaxel.
Subject(s)
Delayed-Action Preparations/chemistry , Delayed-Action Preparations/pharmacology , Drug Delivery Systems/methods , Nanoparticles/chemistry , Paclitaxel/pharmacology , Antineoplastic Agents, Phytogenic/adverse effects , Antineoplastic Agents, Phytogenic/pharmacology , Antineoplastic Agents, Phytogenic/toxicity , Cell Line, Tumor , Drinking Behavior/drug effects , Glycolates/chemistry , Humans , Jurkat Cells , Lactic Acid/chemistry , Paclitaxel/adverse effects , Paclitaxel/toxicity , Polymers/chemistry , Polymers/pharmacology , Polysorbates/chemistry , Polysorbates/pharmacologyABSTRACT
A very rare case of osteopoikilosis, a disease which is an asymptomatic, genotypical osteopathy with an unknown cause, is described. Most often it is discovered by accidental radiography and it is characterized by the appearance of spotted and oval foci of compact cortical and lameral bone inside the canselous bones. The most common localization of these disorders are epiphyses and metaphyses of the long bones. The disorders have a static character and they do not demand any kind of treatment.
