[Use of photosense treatment to enhance photodynamic effect on solid sarcoma-1 in Wistar rats].

Interaction between such components of photodynamic therapy as tumor, intact tissues, lighting and photosensitizers has been investigated. The efficacy of Photosense treatment was demonstrated in the experiments using transplantable tumors in Wistar rats. The photodynamic procedure both inhibited tumor process and stimulated immune system.

[The optimization of a plan for the photodynamic therapy of sarcoma M1 using photosens]. / Optimizatsiia skhemy fotodinamicheskoi terapii sarkomy M1 s primeneniem fotosensa.

The study established the importance of optimal dosage, concentration and mode of administration of the drug Fotosens for the effectiveness of photodynamic therapy of tumor. Of similar importance is the interval between administration and irradiation to potentiate the drug's action. Failure to consider the latter factor may lower the effect dramatically or even reverse it. Experimental findings point to high antitumor potency of the drug. Preference should be given to injecting relatively low concentrations along the periphery of tumor, thus avoiding the undesirable cytostimulating effect and toxicity of Fotosens and saving on the drug. The potential of the treatment as a component of "white light" photodynamic therapy is discussed.