Finite element modelling and experimental validation of a total implanted shoulder joint.

Background Replicating a total shoulder arthroplasty in laboratory is a difficult task due to complex geometry of the structures and degrees of freedom of the joint. Implanted joint shoulders have been investigated using numerical tools, but models developed lack of experimental validation. The objective of this study was to develop a finite element model that replicated correctly an experimental simulator of an implanted joint shoulder based on the comparison of measured and calculated strains. The methods used include a non-cemented Anatomical Comprehensive© Total Shoulder System that was implanted in 4th generation composite bones. The finite element model designed replicates adequately the experimental model. Both models included the most important muscles of shoulder abduction and the same boundary conditions (loads, fixation, and interface conditions). Strain gauge rosettes were used to measure strain responses on the shoulder in 90° abduction. The results of linear regression analysis between numerical and experimental results present a high correlation coefficient of 0.945 and a root-mean-square-error of 35 µÎµ, suggesting adequate agreement between the experimental and the numerical models. Small strains were obtained and changes in load distribution from posterior to anterior region were observed. As conclusion we can say that the experiments allowed good replication of the finite element model, and the use of strain gauges is suitable for numerical-experimental validation of bone joints.

Repetitive Transcorneal Alternating Current Stimulation Reduces Brain Idling State After Long-term Vision Loss.

BACKGROUND: Deafferentation of visual system structures following brain or optic nerve injury leaves cortical areas deprived of visual input. Deprived cortical areas have a reduced sensory information processing and are characterized with localized enhanced or synchronized rhythms believed to represent an "idling state". OBJECTIVE/HYPOTHESIS: We hypothesized that cortical idling can be modified with transcorneal alternating current stimulation (tACS) known to modulate cortical oscillations and thus change the functional state of the deafferented areas. METHODS: tACS was applied in rat model of severe optic nerve crush using a protocol similar to our clinical studies (200 µA, 2-8 Hz) for 5 treatment days right after the lesion and at the chronic stage (3 months later). EEG and VEP were recorded over the visual cortices. In vivo confocal neuroimaging of the retina and histology of the optic nerves were performed. RESULTS: Morphological investigations showed massive retinal ganglion cells death and degeneration of the optic nerves after crush. Visual loss was associated with increased EEG spectral power and lower coherence, indicating an "idling state". Stimulation induced a significant decrease of EEG power towards normal values. These effects were especially pronounced in the chronic stage. CONCLUSION: Our results suggest that alternating current injected via the eye is able to modulate visually deprived brain areas and thus reduce cortical idling.