ABSTRACT
Hepatoblastoma is a rare pediatric malignant tumor of the liver. Previous cytogenetic reports are sporadic. We karyotyped nine consecutive hepatoblastomas from the Italian centers participating in a multicentric study on hepatic tumors (SIOPEL 1). Six cases showed abnormal karyotypes. The most common abnormalities were trisomies of chromosomes 2 and 20. Four cases showed abnormalities of chromosome 1. On the basis of findings, we speculate the possibility of a cytogenetic evolutive pattern of hepatoblastomas.
Subject(s)
Hepatoblastoma/genetics , Liver Neoplasms/genetics , Child, Preschool , Clone Cells/pathology , Female , Hepatoblastoma/pathology , Humans , In Situ Hybridization, Fluorescence , Infant , Karyotyping , Liver Neoplasms/pathology , Male , Neoplasms, Germ Cell and Embryonal/genetics , Neoplasms, Germ Cell and Embryonal/pathology , Tumor Cells, CulturedABSTRACT
A cytogenetic analysis was performed on short-term cultures of 43 previously untreated childhood central nervous system neoplasms of various histology. The cells were obtained from pediatric patients, none of whom had received therapy before karyotypic evaluation. Successful chromosome studies were performed on 24 tumors. The most commonly detected structural abnormalities involved chromosomes 1 and 17. Other structural chromosome abnormalities involved chromosomes 3, 6, 8, 9, 11, 12, and 20.
Subject(s)
Astrocytoma/genetics , Brain Neoplasms/genetics , Carcinoma, Embryonal/genetics , Cerebellar Neoplasms/genetics , Chromosome Aberrations/genetics , Ependymoma/genetics , Medulloblastoma/genetics , Adolescent , Child , Child, Preschool , Chromosome Disorders , Female , Humans , In Situ Hybridization, Fluorescence , Infant , Karyotyping , Male , PloidiesABSTRACT
The translocation of t(8;16)(p11;p13) has been demonstrated in the blasts of a phenotypically normal newborn baby with acute monoblastic leukemia. No antileukemic therapy was administered and spontaneous, complete remission was observed at 2 months of age. The patient remains well 18 months after the diagnosis and continues to have a normal hemogram.
Subject(s)
Chromosomes, Human, Pair 16 , Chromosomes, Human, Pair 8 , Leukemia, Monocytic, Acute/genetics , Translocation, Genetic , Humans , Infant, Newborn , Karyotyping , Male , Remission, Spontaneous , Time FactorsABSTRACT
The reciprocal translocation (11;22)(q24;q12) was observed in a seven day culture from a mesenchymal chondrosarcoma of the bone, a tumor not characterized cytogenetically so far. We suggest that because of the presence of a similar cytogenetic abnormality, mesenchymal chondrosarcoma may belong to the wide group of "t(11;22)-small round cell tumors".
Subject(s)
Bone Neoplasms/genetics , Chondrosarcoma, Mesenchymal/genetics , Chromosomes, Human, Pair 11/ultrastructure , Chromosomes, Human, Pair 22/ultrastructure , Tibia , Translocation, Genetic , Adolescent , Aneuploidy , Bone Neoplasms/classification , Bone Neoplasms/ultrastructure , Chondrosarcoma, Mesenchymal/classification , Chondrosarcoma, Mesenchymal/ultrastructure , Chromosome Aberrations , Humans , MaleABSTRACT
Small round cell tumors are among the most common problems in the differential diagnosis of cancer, even when more sophisticated histological techniques are utilized (Ezinger and Weiss: In Soft Tissue Tumors. St. Louis: CV Mosby, 1988, pp 668-683). Six cases of small round cell tumors are described the diagnosis of which was particularly difficult. Cytogenetic analysis provided useful information in all of them in making the definitive diagnosis. The reported cases stress the value of cytogenetic methods in approaching difficult diagnostic problems.
