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1.
Hb Vaasa or alpha2beta2 (39(C5)Gln replaced by Glu), a mildly unstable variant found in a Finnish family.
Kendall, A G; ten Pas, A; Wilson, J B; Cope, N; Bolch, K; Huisman, T H.
Hemoglobin ; 1(3): 292-5, 1977.
Article in English | MEDLINE | ID: mdl-893132

Subject(s)
Hemoglobins, Abnormal/analysis , Adult , Female , Fetal Hemoglobin/analysis , Glutamates , Glutamine , Hemoglobin A/analysis , Humans
2.
Hb-Volga or alpha 2 beta 2 27(B9)Ala replaced by Asp. An unstable hemoglobin variant in three generations of a Dutch family.
Kuis-Reerink, J D; Jonxis, J H; Niazi, G A; Wilson, J B; Bolch, K C; Gravely, M; Huisman, T H.
Biochim Biophys Acta ; 439(1): 63-9, 1976 Jul 19.
Article in English | MEDLINE | ID: mdl-952960

Subject(s)
Genetic Variation , Hemoglobins, Abnormal , Alanine , Amino Acid Sequence , Anemia, Hemolytic, Congenital Nonspherocytic/blood , Aspartic Acid , Drug Stability , Female , Humans , Male , Pedigree , Protein Conformation
3.
Hemoglobin Hacettepe or alpha 2 beta 2 127 (H5) Gln replaced by Glu.
Altay, C; Altinöz, N; Wilson, J B; Bolch, K C; Huisman, T H.
Biochim Biophys Acta ; 434(1): 1-3, 1976 May 20.
Article in English | MEDLINE | ID: mdl-938658

Subject(s)
Hemoglobins, Abnormal , Adult , Child , Female , Genetic Variation , Glutamates , Glutamine , Humans , Male , Pedigree , Turkey
4.
Hb-Alberta or alpha2beta2 (101(G3) Glu replaced by Gly), a new high-oxygen-affinity hemoglobin variant causing erythrocytosis.
Mant, M J; Salkie, M L; Cope, N; Appling, F; Bolch, K; Jayalakshmi, M; Gravely, M; Wilson, J B; Huisman, T H.
Hemoglobin ; 1(2): 183-94, 1976.
Article in English | MEDLINE | ID: mdl-1052180

ABSTRACT

Hb-Alberta has been found in a 51 year old Caucasian male with erythrocytosis. The substitution in this variant involves the glutamyl residue in position 101(G3) of the beta chain which is replaced by a glycyl residue. Hb-Alberta accounts for about 45% in the heterozygote, and readily forms hybrid tetramers with other hemoglobins. The oxygen affinity of Hb-Alberta is greatly increased, its Bohr effect reduced, and its subunit interaction greatly diminished.


Subject(s)
Hemoglobins, Abnormal/isolation & purification , Polycythemia/etiology , Alberta , Amino Acids/analysis , Electrophoresis, Starch Gel , Genetic Variation , Glutamine/blood , Hemoglobins, Abnormal/analysis , Humans , Lysine/blood , Male , Middle Aged , Oxygen/blood
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