ABSTRACT
Clinical investigations performed in 735 patients have shown that in addition to the improvement of organisation of the medical aid and the universally recognized resuscitation measures for trauma shock, the prophylactics and treatment of intoxication, metabolic, immune and other disorders developing in the patients soon after trauma should be started as early as at the prehospital step.
Subject(s)
First Aid , Shock, Traumatic/therapy , Analgesia , Combined Modality Therapy , Fluid Therapy , Humans , Immobilization , Multiple Trauma/blood , Multiple Trauma/immunology , Multiple Trauma/therapy , Shock, Traumatic/blood , Shock, Traumatic/immunologyABSTRACT
State of energy metabolism was studied in brain of rats at agonal steps caused by bleeding during severe and long-term hypotension (30 mmHg, up to 30 hrs). Fast loss of high energy-containing phosphates, cell energy potential of adenine nucleotides and an increase in the lactate/pyruvate ratio were found in non-resistant rats. At the same time, in the most resistant rats normal content of creatine phosphate, ATP was maintained; energy potential was unaltered and anaerobic glycolysis was not activated. Content of glucose and glycogen did not alter considerably in all the animals studied.
