ABSTRACT
Studies with rats and white mice demonstrated that combined radiation injury (CRI) comes to reducing protease activity in small intestine tissues. In liver tissue the activity of cathepsine D increased under the action of new enterosorbent--clay of Kaluga deposit ("CKD"). In blood serum of the damaged animals the amount of histogenic toxins--middle mass molecules (MMM) and oligopeptides decreased after "CKD" administration. An effective fixation and withdrawal of bacteria from the bowl of the affected animals took place. The survival level of mice in 30 days after CRI comprised 20% as compared with 60% in the case of "CK D" administration. It is supposed that the increase of survival after "CKD" administration is the result of enhancement of macrophage detoxification in liver, determined on the increase of activity of cathepsine D (lysosomal protease), elimination of MMM and normalization of gut microflora.
Subject(s)
Aluminum Silicates/administration & dosage , Enterosorption , Peptide Hydrolases/metabolism , Radiation Injuries, Experimental/drug therapy , Radiation Injuries, Experimental/enzymology , Animals , Cathepsin D/metabolism , Clay , Intestine, Small/drug effects , Intestine, Small/enzymology , Intestine, Small/microbiology , Liver/drug effects , Liver/enzymology , Male , Mice , Radiation Injuries, Experimental/microbiology , Rats , Rats, WistarABSTRACT
The efficacy of pefloxacin, a novel promising antibacterial drug of the group of fluoroquinolones, was studied on mice against doxycycline in the prevention and treatment of infectious complications of radiation/thermal injury. According to the data on the effect of the antibiotics on the resistance to exogenic infection and the development of dysbacteriosis pefloxacin was recommended for the use in the scheme of combined therapy of radiation/thermal injury.
