Compensatory reactions during impairment of granulocytic stem in patients with lung cancer receiving antitumor chemotherapy.

We compared changes in the granulocytic hemopoietic stem in patients with stage III-IV lung cancer receiving cytostatic therapy by the original CVC and standard CAM schemes. In patients treated with the CVC regimen, the granulocytic hemopoietic stem possessed more potent compensatory capacities.

[Myelotoxicity of a plant cytostatic preparation etoposide]. / Mielotoksichnost' tsitostaticheskogo preparata rastitel'nogo proiskhozhdeniia--étoposida.

The myelotoxicity and the hemopoiesis recovery effect of etoposide, an antitumor preparation of the podophyllotoxin group, were experimentally studied on mice. It was found that the main role in the hemopoiesis recovery after etoposide administration is related to accelerated proliferation and increased differentiation of the hemopoietic precursor cells.

[Dry extract of Scutellaria baicalensis as a hemostimulant in antineoplastic chemotherapy in patents with lung cancer]. / Ekstrakt shlemnika baikal'skogo sukhoi v kachestve gemostimuliatora v usloviakh protivoopukholevoi khimioterapii bol'nykh rakom legkogo.

Hemopoiesis was studied in 88 patients with lung cancer during antitumor chemotherapy and its combination with a dry SB extract. Administration of the plant preparation was accompanied with hemopoiesis stimulation, intensification of bone-marrow erythro- and granulocytopoiesis and increase in the content of circulating precursors of the type of erythroid and granulomonocytic colony-forming units.

[Effect of Scutellaria baicalensis extract on the immunologic status of patients with lung cancer receiving antineoplastic chemotherapy]. / Vliianie ékstracta shlemnika baikal'skogo na immunologicheskii status bol'nykh rakom legkogo v usloviiakh protivoopukholevoi khimioterapii.

Cytostatic therapy of patients with lung cancer is attended with decrease in the relative number of T-lymphocytes and their theophylline-resistant population. Patients who were given SB showed a tendency towards increase of these parameters during antitumor chemotherapy. The immunoregulation index (IRI) in this case was approximately twice the background values during the whole period of investigation. The inclusion of SB in the therapeutic complex promotes increase in the number of immunoglobulins A at a stable level of immunoglobulins G.

[The stimulating effect of sialic acid on the processes of postradiation hemopoietic regeneration]. / O stimuliruiushchem vliianii sialovoi kisloty na protsessy postluchevoi regeneratsii gemopoéza.

The possibility of stimulating hemopoiesis inhibited by irradiation with N-acetylneuraminic acid (N-ANA) and the mechanisms of this stimulating effect are considered. A 3-fold N-ANA injection (total dose 150 mg/kg) on days 3, 4, and 5 after irradiation mainly promote the activation of erythropoiesis in the bone marrow. A reliable increase in the amount of erythrokaryocytes in the bone marrow and erythroid colony formation from erythroid precursors (CFU-E) were observed in mice CBA irradiated in a dose of 2.0 g and then received N-ANA. A rise in erythropoietic activity production by bone marrow cells testified that elevation of hemopoiesis inducing microenvironment function is the base of stimulating effect of N-ANA on hemopoiesis.

[Role of mast cells in reactions of the blood system in inflammation]. / Rol' tuchnykh kletok v reaktsiiakh sistemy krovi pri vospalenii.

On the model of the acute infectious peritonitis in mice it is shown that the previously osmotic disruption of the peritoneal mast cell population remarkably affects the inflammatory focus, blood and bone-marrow leukocytic reactions. The initial neutrophil accumulation increase and the earlier and more intensive leukocytosis and activation of granulo-monocytopoiesis are established. At the same time the kinetics of monocytes in inflammatory focus is expressed weaker and testifies to the prolongation of the inflammatory response. Thus, in the natural inflammatory conditions mast cells of the inflammatory focus directly or indirectly modulate leukocytes and hematopoiesis.

[Blood system responses in inflammation and mechanisms of their development]. / Reaktsii sistemy krovi pri vospalenii i mekhanizmy ikh razvitiia.

A model of acute infectious peritonitis in mice demonstrated that the inflammation is attended by marked biphasic activation of bone-marrow granulomonocytopoiesis and that the activation is due in many respects to increased functional activity of elements forming the hemopoiesis-inducing microenvironment. This was suggested by increased colony-stimulating activity of the marrow mononuclear cells and the content of hemopoietic islets in the marrow. The colony-stimulating activity of peripheral blood also increased. It was established that inflammation is also characterized by activation of bone-marrow erythropoiesis, which is linked with increased erythropoietic activity of the hemopoiesis-inducing microenvironment and blood. There was a relation between the hemopoietic changes and the kinetics of leukocytes in the focus of inflammation.