ABSTRACT
Prostate cancer is the most common malignant tumor in men. Recently, a slightly decreased frequency of margin positivity following neoadjuvant bicalutamide treatment due to tumor shrinkage was reported. Trials investigating other anti-androgens in the past also reported lower frequencies of surgical margin positivity, but patients outcome has not improved. In this case, local recurrence was confirmed by needle biopsy in a patient five years following radical prostatectomy for prostate adenocarcinoma. After therapy with 50 mg bicalutamide for a month, the tumour was resected. Despite of detailed histological work-up and immunohistochemistry cancer suspicious lesions were not found. We think that bicalutamide may be capable of masking prostate cancer cells.
Subject(s)
Adenocarcinoma/drug therapy , Androgen Antagonists/adverse effects , Anilides/adverse effects , Neoplasm Recurrence, Local/pathology , Nitriles/adverse effects , Prostatic Neoplasms/drug therapy , Tosyl Compounds/adverse effects , Adenocarcinoma/blood , Adenocarcinoma/pathology , Biopsy, Needle , Humans , Immunohistochemistry , Male , Middle Aged , Neoadjuvant Therapy , Neoplasm Recurrence, Local/blood , Prostate/drug effects , Prostate-Specific Antigen/blood , Prostatectomy , Prostatic Neoplasms/blood , Prostatic Neoplasms/pathologyABSTRACT
Fibrin sealing has proved a successful procedure for a variety of indications in operative gynecologic laparoscopy. Ovaries can be reshaped after cystectomy, serosa and peritoneal defects as well as perforations of the uterus can be sealed with fibrin adhesive. At present, application for salpingotomy, fimbrial eversion and tubal anastomosis is being investigated in clinical studies. Yet larger collectives and a longer follow-up are necessary for a final evaluation of the method. No complications were observed in 75 laparoscopic fibrin sealing performed at our department for established indications. Fibrin adhesive can replace time-consuming, complicated endoscopic sutures. It is an atraumatic tissue-sealing and hemostatic technique, easy in handling, thus leading to a considerable reduction in operation times. The excellent hemostyptic and wound healing characteristics of fibrin adhesive are also an advantage.
PIP: Fibrin sealing has proven successful in a variety of situations in operative gynecologic laparoscopy. Ovaries can be reshaped after cystectomy, serosa and peritoneal defects as well as uterine perforations can be sealed with fibrin adhesive. At the present time, application for salpingostomy, fimbrial eversion, and tubal anastomosis are being investigated in clinical studies. Larger samples and longer follow-up periods are necessary for a final evaluation of the method. No complications were observed in 75 laparoscopic fibrin sealings performed at the authors' department. Fibrin adhesive can replace time-consuming, complicated endoscopic sutures. It is an atraumatic tissue sealing and hemostatic technique, easy in handling, and thus leading to a considerable reduction in operation times. The excellent hemostyptic and wound healing characteristics of fibrin adhesive are also an advantage. (author's modified)
