Subject(s)
Angina Pectoris/diagnosis , C-Reactive Protein/analysis , Adult , Aged , Angina Pectoris/blood , Female , Humans , Male , Middle AgedABSTRACT
The role of parathyroid hormone related protein (PTHRP) as a humoral mediator of hypercalcaemia was investigated in a patient with lymphocyte depleted Hodgkin's disease during an episode of hypercalcaemia, using an immunohistochemical staining technique for PTHRP on the tumour tissue and an immunoradiometric (IRMA) assay for PTHRP1-86 on the patient's plasma. The plasma PTHRP was less than 0.23 pmol/l in the range found in normocalcaemic controls, and the immunohistochemical staining was not positive for protein. PTHRP did not have a role in the pathogenesis of hypercalcaemia in this patient.
Subject(s)
Hodgkin Disease/complications , Hypercalcemia/etiology , Neoplasm Proteins/analysis , Proteins/analysis , Aged , Hodgkin Disease/metabolism , Humans , Hypercalcemia/metabolism , Male , Parathyroid Hormone-Related Protein , Peptide Fragments/pharmacology , Proteins/pharmacologyABSTRACT
A 42-year-old man developed transient loss of vision in both eyes. On echocardiography to investigate a systolic murmur and determine the potential source of emboli, a large left atrial myxoma was diagnosed. This was removed successfully leaving no visual or neurological deficit.
