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Biophys Chem
; 312: 107268, 2024 Sep.
Article
in English
| MEDLINE
| ID: mdl-38843749
ABSTRACT
The thermal effect of the formation of the "burst-phase" folding intermediate has been studied using a titration calorimeter. It is shown that, unlike the total thermal effect of native structure formation, it can be both positive and negative depending on the temperature. The reasons for this paradoxical behavior are analyzed. A conclusion is drawn about the leading role of dehydration of non-polar groups in the first stage of folding.