[Tanfelam: synthesis, study of ovicidal activity, and acute toxicity]. / Sintez, issledovanie ovitsidnoi aktivnosti i ostroi toksichnosti preparata Tanfelama.

The papers describes the synthesis of N-(2-piperidinoethyl)-N-tosyl-n-anisidine (Tanfelam) which showed a 100% ovicidal activity when tested by the Harada and Mori methods (in vitro inhibited N.brasiliensis hatching and development test). Tanfelam has been transferred for in-depth tests.

[The search for new antiparasitic agents. 9. The anthelmintic activity of halogen-containing sulfonamidobenzamides]. / Izyskanie novykh protivoparazitarnykh sredstv. 9. Protivogel'mintnaia aktivnost' galoidsoderzhashchikh sul'fonamidobenzamidov.

The results of preclinical trials of 28 new compounds of haloid-containing sulfamidobenzamides with low toxicity are presented. The trials on a hymenolepiasis model showed that effectiveness of N-(2,5-dichlorophenyl)-2/(3-nitro-4-chlorophenyl) sulfonylamino/-5-bromobenzamide was similar to that of the well-known drug niclosamide. In the trials on an opisthorchiasis model, 2 compounds were shown to be highly effective, and on a trichocephaliasis model 5 compounds showed a high activity.

[The search for new antiparasitic agents. 7. A study of the relationship between the structure and the anthelmintic activity of new halogen-containing benzamides]. / Izyskanie novykh protivoparazitarnykh sredstv. 8. Izuchenie sviazi mezhdu stroeniem i protivogel'mintnoi aktivnost'iu novykh galoidsoderzhashchikh benzamidov.

Anthelminthic properties of new series of haloid-containing benzamides have been studied. The anthelminthic activity-structure relationships of the compounds under study has been examined. A number of highly active compounds promising for further investigations have been identified.

[The search for new antiparasitic agents. 4. The study of the antimalarial activity of N-(halogen naphthyloxy)-2-hydroxy-3,5-dihalogen benzamides]. / Poisk novykh protivoparazitarnykh sredstv. Soobshchenie 4. Izuchenie protivomaliariinoi aktivnosti N-(galoidnaftiloksi)-2-gidroksi-3,5-digaloidbenzamidov.

Antimalarial activity of 10 N-(haloidnaphthyloxy)-2-hydroxy-3,5-dihaloidbenzamide compounds earlier synthesized as potential anthelmintics has been studied. It has been shown that antimalarial activity is typical only of amides of 2-hydroxy-3,5-diiodinebenzoic acid.

[The search for new antiparasitic agents. 2. The synthesis and study of the acute toxicity of new halogen-containing sulfonamidobenzamides]. / Izyskanie novykh protivoparazitarnykh sredstv. Soobshchenie 2. Sintez i izuchenie ostroi toksichnosti novykh galoidsoderzhashchikh sul'fonamidobenzamidov.

Novel derivatives of sulfamidobenzamides have been synthesized and tested for acute toxicity. All the compounds were shown to possess a low toxicity. It was suggested that the investigated sulfamidobenzamides might be a promising group among which to search for agents having anthelminthic activity.

[The search for new antiparasitic agents. 1. The synthesis and study of the acute toxicity of new halogen-containing benzamides]. / Izyskanie novykh protivoparazitarnykh sredtsv. Soobshchenie 1. Sintez i izuchenie ostroi toksichnosti novykh galoidsoderzhashchikh benzamidov.

The paper presents the results of toxicological study of 44 compounds of the benzamide series synthesized during search for new anthelminthic agents. The dependence of the toxic effect of the benzamides synthesized on their structure is analysed. The experiments were carried out on white mice given the compounds under study once orally. The maximum tolerated doses of the compounds are presented. It has been found that 34 out of 44 compounds have a low toxicity and are worth of further anthelminthic screening.