Subject(s)
Nervous System Diseases/therapy , Pain Management , Pelvis , Prostatitis/therapy , Chronic Disease , Humans , Male , SyndromeSubject(s)
Anticonvulsants/therapeutic use , Back Pain/drug therapy , gamma-Aminobutyric Acid/analogs & derivatives , Adult , Aged , Anticonvulsants/administration & dosage , Back Pain/physiopathology , Dose-Response Relationship, Drug , Female , Follow-Up Studies , Humans , Male , Middle Aged , Pain Measurement , Pregabalin , Treatment Outcome , gamma-Aminobutyric Acid/administration & dosage , gamma-Aminobutyric Acid/therapeutic useABSTRACT
Psychoemotional disorders were studied in 57 patients aged 26-44 years (mean age 36.2 +/- 6.9 years) with noninflammatory chronic pelvic pain syndrome (CPPS). The disease duration varied from 1 to 5 years. Pain syndrome, anxiety, depression, sexual disorders were assessed by Visual Analogue Scale, Spilberger's Scale, Beck's Scale, International Index of Erectile Function, respectively. All the patients received milnacipran in a daily dose 100 mg. The effect was assessed in 54 patients. Pain syndrome regressed moderately (by 26.1%). The degree of anxiety, depression and sexual disorders diminished to mild. Thus, milnacipran (ixel) demonstrated its efficacy in the treatment of anxiodepressive disorders and psychogenic erectile dysfunction in patients with noninflammatory CPPS.
Subject(s)
Antidepressive Agents/therapeutic use , Anxiety/drug therapy , Cyclopropanes/therapeutic use , Depression/drug therapy , Pelvic Pain/drug therapy , Sexual Dysfunctions, Psychological/drug therapy , Adult , Antidepressive Agents/administration & dosage , Anxiety/complications , Anxiety/psychology , Cyclopropanes/administration & dosage , Depression/complications , Depression/psychology , Humans , Male , Milnacipran , Pelvic Pain/etiology , Pelvic Pain/psychology , Sexual Dysfunctions, Psychological/etiology , Treatment OutcomeABSTRACT
Emotional-painful stress in rats was shown to decrease insignificantly transmembrane cardiomyocyte potential (TCP) measured in isolated hearts. The recovery of TCP following its depression due to the preparation cooling was twice slower in stress-exposed than in control animals. This is in keeping with the data on stress-induced disturbances of Na, K-ATPase activity (an enzyme playing a leading role in TCP maintenance). It is suggested that the disturbance in cation pump function activity plays a certain role in the onset of arrhythmias and cardiac fibrillation during stress.
