Clinical study of the efficiency of Poetam in the treatment of the anemic syndrome in pubertal uterine hemorrhages.

Clinical study of the efficiency of Poetam (affinity-purified antibodies to recombinant human erythropoietin) in the treatment of anemia in patients with pubertal uterine hemorrhages proved that combined therapy with Poetam and iron preparation normalized erythron parameters, structural and metabolic status of erythrocytes, and ferrokinetic parameters of the peripheral blood sooner than monotherapy with Poetam or sorbifer.

Estimation of the prevalence and causes of infertility in western Siberia.

The study examined the epidemiology and causes of infertility in Tomsk, Western Siberia, using methodological approaches recommended by WHO and was based on the findings for a randomly selected sample of 2000 married women aged 18-45 years. Among the respondents, 333 couples were considered infertile since they had not conceived after 12 months or more of unprotected intercourse. This group of infertile couples was offered comprehensive clinical investigations but only 186 couples completed them. The infertility rate in Tomsk was 16.7%, being caused by diseases of the female reproduction system in 52.7% of the couples and by male reproductive diseases in 6.4%. In 38.7% of couples, both spouses suffered from infertility, while in 2.2% of cases the cause of infertility was not determined. Among the causes of female infertility, secondary infertility dominated (12.9% of all the women questioned), while primary infertility affected 3.8% of the women. The most frequent causes of female infertility were disturbances to tubal patency (36.5%) and pelvic adhesions (23.6%). Endocrine pathology was found in 32.8% of cases. The most frequent cause of male infertility was inflammatory disease of male accessory glands (12.9%). In 8.6% of cases infection resulted in obstructive azoospermia. Varicocele was registered in 11.3% of cases, and idiopathic pathospermia in 20.9%. Inflammatory complications among females were 4.2 times more frequent than among males.

PIP: In the first study to investigate the reproductive function of the couple at the population level in the Russian Federation, methodological approaches recommended by the World Health Organization (WHO) were used to analyze the causes of infertility in Western Siberia. In the first stage, interviews were conducted with 2000 randomly selected married women from the city of Tomsk. A total of 333 couples (16.7%) were considered infertile since they had not conceived after 12 months or more of unprotected intercourse. 3.8% of couples suffered from primary infertility and 12.9% from secondary infertility; 24.1% of women in the latter group had experienced complications associated with birth or abortion. Rigorous clinical investigation of 168 couples identified causes of infertility in both partners in 38.7%, in the female partner only in 52.7%, and in the male partner only in 6.4%. More than one cause was present in 80 women (43%). The most frequent causes of female infertility were disturbances to tubal patency (36.5%) and pelvic adhesions (23.6%). Endocrine pathology was found in 32.8% of cases. In men, the most frequent causes were idiopathic infertility or pathospermia (20.9%) and varicocele (11.3%). Inflammatory complications were 4.2 times more frequent among women than men. The 16.7% frequency of infertility in Western Siberia exceeds the 15% critical level defined by WHO.