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Farmakol Toksikol ; 51(2): 94-7, 1988.
Article in Russian | MEDLINE | ID: mdl-3378617

ABSTRACT

It was found that a preliminary administration of phenobarbital to rats caused an increase of the rate of 125I-bilignost excretion in the bile by 46.6% but reduced its half-life in the blood by 48.3% and its excretion in the urine by 46.4%. Phenobarbital decreased the rate of 125I-bilignost absorption by the liver slices and increased the rate of release from them.


Subject(s)
Bile/drug effects , Contrast Media/pharmacokinetics , Iodipamide/pharmacokinetics , Phenobarbital/pharmacology , Animals , Bile/metabolism , Dose-Response Relationship, Drug , Half-Life , In Vitro Techniques , Iodine Radioisotopes , Liver/drug effects , Liver/metabolism , Male , Rats , Time Factors , Tissue Distribution
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