ABSTRACT
In this work, an iterative method based on the four-microphone transfer matrix approach was developed for evaluating the sound speed and attenuation constant of air within a standing wave tube. When the air inside the standing wave tube is treated as the material under test, i.e., as if it were a sample of porous material, the transfer matrix approach can be used to identify the air's acoustic properties. The wavenumber within the tube is complex owing to the formation of a visco-thermal boundary layer on the inner circumference of the tube. Starting from an assumed knowledge of the air properties, an iterative method can be applied in the post-processing stage to estimate the complex wavenumber. Experimental results presented here show that although the results are sensitive to ambient temperature, a semi-empirical formula previously proposed by Temkin [(1981). Elements of Acoustics (John Wiley & Sons)] matches closely with the measured sound speed and attenuation constant, as does a theoretical formulation proposed by Lahiri et al. [(2014). J. Sound Vib. 333(15), 3440-3458]. Further, it is shown that the Temkin [(1981). Elements of Acoustics (John Wiley & Sons)] and Lahiri et al. [(2014). J. Sound Vib. 333(15), 3440-3458] predictions accurately represent the variation of sound speed with frequency, in contrast to the formula recommended in the ASTM E1050 standard [(2019). American Society for Testing and Materials], in which the sound speed is assumed to be independent of frequency.
ABSTRACT
Near-field acoustical holography (NAH) is a useful tool for sound field reconstruction and sound source identification. In NAH, a basis model is first selected to represent the physical sound field, and then a near-field measurement is made with a microphone array. Next, the parameters in the selected model can be estimated based on the measurements by using an inverse approach, resulting in the sound field near the source being reconstructed so that the sound source location can be identified. But, in addition to being able to reconstruct the near-field of a source, the far-field can also be predicted with the identified sound source model. A significant amount of work has been performed to study the near-field reconstruction capability of different NAH algorithms, but there has been a limited number of publications in which the far-field prediction accuracy, based on the near-field measurement constructed model, has been considered. In the present experimental work, two multi-transducer loudspeakers were placed side-by-side to create a multi-component sound source, and two sets of measurements were conducted: an intensity probe scanned the sound field generated by the loudspeakers in both the near-field (0.05 m) and far-field (0.48 m) such that the true near- and far-field intensity spatial distributions and total sound power could be identified. Then, based on the near-field pressure measurements, four acoustical holography algorithms, statistically optimized near-field acoustical holography, wideband acoustical holography, l1-norm minimization, and a hybrid compressive sampling method were used to predict the near- and far-field sound intensity distributions. The near- and far-field prediction results were compared with the direct measurement, and the sound field reconstruction accuracy was studied. It was found that all of the algorithms were able to reconstruct the near-field well when the near-field measurements were used to construct the model. It was found that with the abovementioned models, far-field reconstructions could correctly predict the spatial sound field distribution, but in all of the cases, the total sound power was underestimated.
ABSTRACT
The acoustical behavior of air-saturated aerogel powders in the audible frequency range is not well understood. It is not clear, for example, which physical processes control the acoustic absorption and/or attenuation in a very light, loose granular mix in which the grain diameter is on the order of a micron. The originality of this work is the use of a Biot-type poro-elastic model to fit accurately the measured absorption coefficients of two aerogel powders with particle diameters in the range 1-40 µm. It is shown that these materials behave like a viscoelastic layer and their absorption coefficient depends strongly on the root mean square sound pressure in the incident wave. Furthermore, it was found that the loss factor controlling the energy dissipation due to the vibration of the elastic frame is a key model parameter. The value of this parameter decreased progressively with the frequency and sound pressure. In contrast, other fitted parameters in the Biot-type poro-elastic model, e.g., the stiffness of the elastic frame and pore size, were found to be relatively independent of the frequency and amplitude of the incident wave. It is shown that these materials absorb acoustic waves very efficiently around the frequencies of the frame resonance.
ABSTRACT
Kelp forests are declining in many regions globally with climatic perturbations causing shifts to alternate communities and significant ecological and economic loss. Range edge populations are often at most risk and are often only sustained through localised areas of upwelling or on deeper reefs. Here we document the loss of kelp forests (Ecklonia radiata) from the Sultanate of Oman, the only confirmed northern hemisphere population of this species. Contemporary surveys failed to find any kelp in its only known historical northern hemisphere location, Sadah on the Dhofar coast. Genetic analyses of historical herbarium specimens from Oman confirmed the species to be E. radiata and revealed the lost population contained a common CO1 haplotype found across South Africa, Australia and New Zealand suggesting it once established through rapid colonisation throughout its range. However, the Omani population also contained a haplotype that is found nowhere else in the extant southern hemisphere distribution of E. radiata. The loss of the Oman population could be due to significant increases in the Arabian Sea temperature over the past 40 years punctuated by suppression of coastal upwelling. Climate-mediated warming is threatening the persistence of temperate species and precipitating loss of unique genetic diversity at lower latitudes.
Subject(s)
Kelp , Ecosystem , Forests , Kelp/genetics , Oman , TemperatureABSTRACT
Acoustic radiation modes (ARMs) have been widely used in noise control engineering. For an arbitrarily shaped radiator, ARMs are usually obtained by using the boundary element method (BEM). For high frequencies and large structures, the BEM calculation is usually time consuming. An alternative method was recently developed in which the ARMs are obtained by using generalized singular value decomposition and spherical harmonic functions. In this paper, spheroidal harmonic functions are used instead of spherical harmonic functions. The proposed method is potentially more efficient for ARM calculations for structures with one dimension significantly larger than the other two.
ABSTRACT
AIMS: Although immune-mediated inflammatory diseases (IMID) are associated with multiple mental health conditions, there is a paucity of literature assessing personality disorders (PDs) in these populations. We aimed to estimate and compare the incidence of any PD in IMID and matched cohorts over time, and identify sociodemographic characteristics associated with the incidence of PD. METHODS: We used population-based administrative data from Manitoba, Canada to identify persons with incident inflammatory bowel disease (IBD), multiple sclerosis (MS) and rheumatoid arthritis (RA) using validated case definitions. Unaffected controls were matched 5:1 on sex, age and region of residence. PDs were identified using hospitalisation or physician claims. We used unadjusted and covariate-adjusted negative binomial regression to compare the incidence of PDs between the IMID and matched cohorts. RESULTS: We identified 19 572 incident cases of IMID (IBD n = 6,119, MS n = 3,514, RA n = 10 206) and 97 727 matches overall. After covariate adjustment, the IMID cohort had an increased incidence of PDs (incidence rate ratio [IRR] 1.72; 95%CI: 1.47-2.01) as compared to the matched cohort, which remained consistent over time. The incidence of PDs was similarly elevated in IBD (IRR 2.19; 95%CI: 1.69-2.84), MS (IRR 1.79; 95%CI: 1.29-2.50) and RA (IRR 1.61; 95%CI: 1.29-1.99). Lower socioeconomic status and urban residence were associated with an increased incidence of PDs, whereas mid to older adulthood (age 45-64) was associated with overall decreased incidence. In a restricted sample with 5 years of data before and after IMID diagnosis, the incidence of PDs was also elevated before IMID diagnosis among all IMID groups relative to matched controls. CONCLUSIONS: IMID are associated with an increased incidence of PDs both before and after an IMID diagnosis. These results support the relevance of shared risk factors in the co-occurrence of PDs and IMID conditions.
Subject(s)
Arthritis, Rheumatoid/epidemiology , Immune System Diseases/complications , Inflammation/complications , Inflammatory Bowel Diseases/epidemiology , Multiple Sclerosis/epidemiology , Personality Disorders/epidemiology , Adolescent , Adult , Canada/epidemiology , Cohort Studies , Comorbidity/trends , Female , Humans , Immune System Diseases/epidemiology , Incidence , Inflammation/epidemiology , Male , Manitoba/epidemiology , Middle Aged , Personality Disorders/psychology , Risk Factors , Socioeconomic Factors , Young AdultABSTRACT
Acoustic radiation modes (ARMs) have been widely used in noise control engineering owing to their convenient sound-power characteristics. However, the evaluation of ARMs for non-regular structures can be computationally intensive: it usually involves solving the boundary integral equation (BIE) by using the boundary element method in order to obtain the sound power radiation resistance matrix, followed by a singular value decomposition to obtain the radiation modes. The proposed procedure involves projecting spherical harmonics onto an enclosing surface, followed by the application of generalized singular value decomposition, with the result that the need to solve the BIE is eliminated, which potentially reduces the computational effort significantly.
ABSTRACT
Near-field Acoustical Holography is a powerful tool for sound source identification and sound field reconstruction. Generally, many microphone measurements are required to construct a source model that can span the whole sound source region while simultaneously avoiding measurement errors and ensuring a high spatial sampling rate. That type of measurement is economically costly and hard to perform in industrial environments. Motivated by the desire to be able to use a relatively small number of microphone measurements to reconstruct a sound field and to accurately identify sound source locations, an Equivalent Source Method (ESM) is considered here. In particular, the focus is on the combination of a monopole-distribution ESM and a relatively small number of microphone measurements, thus creating an under-determined system. Wideband Acoustical Holography and l1-norm Convex Optimization are introduced to solve this under-determined inverse problem. Based on the attributes of these two methods, a hybrid method combining the best features of each is proposed to identify sound source locations.
ABSTRACT
BACKGROUND: Human papillomavirus type 16 (HPV16)-E6 antibodies are detectable in peripheral blood before diagnosis in the majority of HPV16-driven oropharyngeal squamous cell carcinoma (OPSCC), but the timing of seroconversion is unknown. PATIENTS AND METHODS: We formed the HPV Cancer Cohort Consortium which comprises nine population cohorts from Europe, North America and Australia. In total, 743 incident OPSCC cases and 5814 controls provided at least one pre-diagnostic blood sample, including 111 cases with multiple samples. Median time between first blood collection and OPSCC diagnosis was 11.4 years (IQR = 6-11 years, range = 0-40 years). Antibodies against HPV16-E6 were measured by multiplex serology (GST fusion protein based Luminex assay). RESULTS: HPV16-E6 seropositivity was present in 0.4% of controls (22/5814; 95% CI 0.2% to 0.6%) and 26.2% (195/743; 95% CI 23.1% to 29.6%) of OPSCC cases. HPV16-E6 seropositivity increased the odds of OPSCC 98.2-fold (95% CI 62.1-155.4) in whites and 17.2-fold (95% CI 1.7-170.5) in blacks. Seropositivity in cases was more frequent in recent calendar periods, ranging from 21.9% pre-1996 to 68.4% in 2005 onwards, in those with blood collection near diagnosis (lead time <5 years). HPV16-E6 seropositivity increased with lead time: 0.0%, 13.5%, 23.7%, and 38.9% with lead times of >30 years (N = 24), 20-30 years (N = 148), 10-20 years (N = 228), and <10 years (N = 301 cases) (p-trend < 0.001). Of the 47 HPV16-E6 seropositive cases with serially-collected blood samples, 17 cases seroconverted during follow-up, with timing ranging from 6 to 28 years before diagnosis. For the remaining 30 cases, robust seropositivity was observed up to 25 years before diagnosis. CONCLUSIONS: The immune response to HPV16-driven tumorigenesis is most often detectable several decades before OPSCC diagnosis. HPV16-E6 seropositive individuals face increased risk of OPSCC over several decades.
Subject(s)
Antibodies, Viral/blood , Human papillomavirus 16/immunology , Oropharyngeal Neoplasms/diagnosis , Papillomavirus Infections/diagnosis , Squamous Cell Carcinoma of Head and Neck/diagnosis , Adult , Aged , Carcinogenesis/immunology , Case-Control Studies , Female , Follow-Up Studies , Human papillomavirus 16/isolation & purification , Humans , Male , Middle Aged , Oncogene Proteins, Viral/immunology , Oropharyngeal Neoplasms/blood , Oropharyngeal Neoplasms/immunology , Oropharyngeal Neoplasms/virology , Papillomavirus Infections/blood , Papillomavirus Infections/immunology , Papillomavirus Infections/virology , Prospective Studies , Repressor Proteins/immunology , Seroconversion , Squamous Cell Carcinoma of Head and Neck/blood , Squamous Cell Carcinoma of Head and Neck/immunology , Squamous Cell Carcinoma of Head and Neck/virology , Time FactorsABSTRACT
These data present associations between socioeconomic status (SES), different types of childhood maltreatment (CM) history and family dysfunction, and arthritis in men and women across a wide age range. Arthritis was less likely among those with higher SES, regardless of CM history. INTRODUCTION: CM has been associated with increased risk of adult-onset arthritis; however, little is known about whether socioeconomic status moderates arthritis risk in those with CM history. We investigated arthritis across education, income, and race/ethnicity and whether CM moderated associations between SES and arthritis. METHODS: Data were drawn from Wave 2 (2004-2005) of the nationally representative (USA) National Epidemiological Survey on Alcohol and Related Conditions (NESARC, n = 34,563; aged ≥ 20 years). Self-reported CM history included physical abuse, sexual abuse, emotional abuse, emotional neglect, physical neglect, and exposure to intimate partner violence (IPV). We used descriptive statistics and logistic regression to determine relationships between SES, CM, and arthritis. Interaction terms were used to test if CM moderated relationships between SES and arthritis. RESULTS: Arthritis prevalence was 21.1% (n = 3093) among men and 30.1% (n = 6167) among women. In unadjusted analyses, women (p ≤ 0.001) and older age (both sexes, p ≤ 0.01) were associated with increased odds of arthritis. All CM types were associated with increased odds of arthritis, except exposure to IPV among women. In sex-stratified, age-adjusted analyses, lower education and income, family dysfunction, being Hispanic or Asian/Native Hawaiian/Pacific Islander, and ≥ 1 physical comorbidity were associated with increased odds of arthritis among those with and without CM: trends were similar for both sexes. In age-adjusted two-way interaction terms, CM did not moderate associations between SES and arthritis. CONCLUSIONS: Although CM was associated with arthritis, associations between SES and arthritis were not amplified. Arthritis was less likely among those with higher SES, regardless of CM history.
Subject(s)
Adult Survivors of Child Abuse/statistics & numerical data , Arthritis/etiology , Child Abuse/statistics & numerical data , Adult , Age Distribution , Aged , Aged, 80 and over , Arthritis/epidemiology , Child , Chronic Disease/epidemiology , Cross-Sectional Studies , Female , Health Surveys , Humans , Male , Middle Aged , Prevalence , Risk Factors , Sex Distribution , Social Class , Socioeconomic Factors , United States/epidemiology , Young AdultABSTRACT
AIMS: After the diagnosis of immune-mediated inflammatory diseases (IMID) such as inflammatory bowel disease (IBD), multiple sclerosis (MS) and rheumatoid arthritis (RA), the incidence of psychiatric comorbidity is increased relative to the general population. We aimed to determine whether the incidence of psychiatric disorders is increased in the 5 years before the diagnosis of IMID as compared with the general population. METHODS: Using population-based administrative health data from the Canadian province of Manitoba, we identified all persons with incident IBD, MS and RA between 1989 and 2012, and cohorts from the general population matched 5 : 1 on year of birth, sex and region to each disease cohort. We identified members of these groups with at least 5 years of residency before and after the IMID diagnosis date. We applied validated algorithms for depression, anxiety disorders, bipolar disorder, schizophrenia, and any psychiatric disorder to determine the annual incidence of these conditions in the 5-year periods before and after the diagnosis year. RESULTS: We identified 12 141 incident cases of IMID (3766 IBD, 2190 MS, 6350 RA) and 65 424 matched individuals. As early as 5 years before diagnosis, the incidence of depression [incidence rate ratio (IRR) 1.54; 95% CI 1.30-1.84) and anxiety disorders (IRR 1.30; 95% CI 1.12-1.51) were elevated in the IMID cohort as compared with the matched cohort. Similar results were obtained for each of the IBD, MS and RA cohorts. The incidence of bipolar disorder was elevated beginning 3 years before IMID diagnosis (IRR 1.63; 95% CI 1.10-2.40). CONCLUSION: The incidence of psychiatric comorbidity is elevated in the IMID population as compared with a matched population as early as 5 years before diagnosis. Future studies should elucidate whether this reflects shared risk factors for psychiatric disorders and IMID, a shared final common inflammatory pathway or other aetiology.
Subject(s)
Arthritis, Rheumatoid/epidemiology , Inflammatory Bowel Diseases/epidemiology , Mental Disorders/epidemiology , Multiple Sclerosis/epidemiology , Adult , Comorbidity/trends , Female , Humans , Incidence , Male , Manitoba/epidemiology , Middle Aged , Risk FactorsABSTRACT
The equivalent source methods (ESM) that have been developed to this point can generally be classified into two categories: one in which a relatively large number of lower order sources are fixed at various locations, and one in which a series of higher order sources are fixed at one location. The present work started with a model in the latter category, but the individual sources were then allowed to move separately to locations which were determined by using a nonlinear optimization procedure based on the measured sound field data. To test this approach, experiments were conducted using a small loudspeaker cabinet; measurements were made using an array of microphones on all sides of the loudspeaker. It was found that by allowing the source components to move, the sound field representation in both the near and far fields was improved, particularly at high frequencies, compared to the model with fixed source locations. By comparison with results obtained from boundary element calculations based on laser vibrometer measurements of the loudspeaker's diaphragm and tweeter velocities, it was found that the proposed ESM can also be used to accurately predict the sound pressure distribution on the source surface.
ABSTRACT
Based on the idea that a layer of properly designed and manufactured fibrous material can serve as both a sound absorber and a structural damper, an approach is introduced in this article to design the microstructure of a fibrous layer for it to provide optimal damping performance. To begin with, previous work related to structural damping by fibrous layers was reviewed. Then the most appropriate models from the literature were adapted for use in the current study. A system comprising an aluminum panel and a limp fibrous layer was driven by a line force, and both the spatial velocity response of the panel and the power distribution within the system were calculated to quantify the degree of damping provided by the fibrous layer, which helped identify the airflow resistivity that provides optimal damping for any frequency and panel of interest. Given the optimal airflow resistivity, a model relating fiber microstructure to airflow resistivity was used to infer the optimal microstructure required to achieve the optimal damping performance. One finding of the current work, for example, was that as the target frequency was reduced, the fiber size required to achieve the optimal damping performance increased.
ABSTRACT
Resilience to stress-related emotional disorders is governed in part by early-life experiences. Here we demonstrate experience-dependent re-programming of stress-sensitive hypothalamic neurons, which takes place through modification of neuronal gene expression via epigenetic mechanisms. Specifically, we found that augmented maternal care reduced glutamatergic synapses onto stress-sensitive hypothalamic neurons and repressed expression of the stress-responsive gene, Crh. In hypothalamus in vitro, reduced glutamatergic neurotransmission recapitulated the repressive effects of augmented maternal care on Crh, and this required recruitment of the transcriptional repressor repressor element-1 silencing transcription factor/neuron restrictive silencing factor (NRSF). Increased NRSF binding to chromatin was accompanied by sequential repressive epigenetic changes which outlasted NRSF binding. chromatin immunoprecipitation-seq analyses of NRSF targets identified gene networks that, in addition to Crh, likely contributed to the augmented care-induced phenotype, including diminished depression-like and anxiety-like behaviors. Together, we believe these findings provide the first causal link between enriched neonatal experience, synaptic refinement and induction of epigenetic processes within specific neurons. They uncover a novel mechanistic pathway from neonatal environment to emotional resilience.
Subject(s)
Corticotropin-Releasing Hormone/genetics , Neuronal Plasticity/genetics , Repressor Proteins/genetics , Animals , Animals, Newborn/metabolism , Animals, Newborn/psychology , Chromatin/metabolism , Epigenesis, Genetic/genetics , Excitatory Amino Acid Agents/metabolism , Female , Humans , Hypothalamus , Male , Neurons/metabolism , RNA, Messenger/metabolism , Rats , Rats, Sprague-Dawley , Repressor Proteins/metabolism , Resilience, Psychological , Transcription Factors/genetics , Transcription, GeneticABSTRACT
Though the ultrasonic excitation of surface waves in solids is generally realized through the use of a contact transducer, remote excitation would enable standoff testing in applications such as the nondestructive evaluation of structures. With respect to the optimal incident wave profile, bounded inhomogeneous waves, which include an exponentially decaying term, have been shown to improve the surface wave excitation efficiency as compared to Gaussian and square waves. The purpose of this work is to investigate the effect of varying the incident wave spatial decay rate, as applied to both lossless fluid-solid interfaces and to solids with viscoelastic losses included. The Fourier method is used to decompose the incident profile and subsequently compute the reflected wave profile. It is shown that inhomogeneous plane wave theory predicts, to a close approximation, the location of the minimum in the local reflection coefficient with respect to the decay rate for bounded incident waves. Moreover, plane wave theory gives a reasonable indication of the decay rate that maximizes the surface wave excitation efficiency.
ABSTRACT
The metamaterial under investigation here consists of a periodic arrangement of unit plates in a grid-like frame such that there is a contrast in the local areal mass between cell interior and cell wall. In the low frequency range and under normal incidence this metamaterial panel exhibits a sound transmission loss significantly larger than the transmission loss of an unstructured panel with the same homogeneous mass per unit area. However, when the incident sound field is diffuse, the relative advantage of the metamaterial barrier is reduced or eliminated. A sequence of experiments is documented to demonstrate that the relative advantage of the metamaterial barrier can be realized even in a diffuse sound field by creating a hybrid barrier system which embeds the metamaterial layer between a normalizing waveguide layer on the incident side and an absorbing layer on the transmitted side. The sound normalizing waveguide layer is a lattice structure, and the absorbing layer is high performance glass fiber mat. By using measurements of the transmission loss of a 1.2 m square panel system the role of each of these components is demonstrated.
ABSTRACT
The (Cartesian) multipole series, i.e., the series comprising monopole, dipoles, quadrupoles, etc., can be used, as an alternative to the spherical or cylindrical wave series, in representing sound fields in a wide range of problems, such as source radiation, sound scattering, etc. The proofs of the completeness of the spherical and cylindrical wave series in these problems are classical results, and it is also generally agreed that the Cartesian multipole series spans the same space as the spherical waves: a rigorous mathematical proof of that statement has, however, not been presented. In the present work, such a proof of the completeness of the Cartesian multipole series, both in two and three dimensions, is given, and the linear dependence relations among different orders of multipoles are discussed, which then allows one to easily extract a basis from the multipole series. In particular, it is concluded that the multipoles comprising the two highest orders in the series form a basis of the whole series, since the multipoles of all the lower source orders can be expressed as a linear combination of that basis.
ABSTRACT
BACKGROUND: Depression and anxiety are common in persons with multiple sclerosis (MS), and adversely affect fatigue, medication adherence, and quality of life. Though effective treatments for depression and anxiety exist in the general population, their applicability in the MS population has not been definitively established. OBJECTIVE: To determine the overall effect of psychological and pharmacological treatments for depression or anxiety in persons with MS. METHODS: We searched the Medline, EMBASE, PsycINFO, PsycARTICLES Full Text, Cochrane Central Register of Controlled Trials, CINAHL, Web of Science, and Scopus databases using systematic review methodology from database inception until March 25, 2015. Two independent reviewers screened abstracts, extracted data, and assessed risk of bias and strength of evidence. We included controlled clinical trials reporting on the effect of pharmacological or psychological interventions for depression or anxiety in a sample of persons with MS. We calculated standardized mean differences (SMD) and pooled using random effects meta-analysis. RESULTS: Of 1753 abstracts screened, 21 articles reporting on 13 unique clinical trials met the inclusion criteria. Depression severity improved in nine psychological trials of depression treatment (N=307; SMD: -0.45 (95%CI: -0.74, -0.16)). The severity of depression also improved in three pharmacological trials of depression treatment (SMD: -0.63 (N=165; 95%CI: -1.07, -0.20)). For anxiety, only a single trial examined psychological therapy for injection phobia and reported no statistically significant improvement. CONCLUSION: Pharmacological and psychological treatments for depression were effective in reducing depressive symptoms in MS. The data are insufficient to determine the effectiveness of treatments for anxiety.