1.
Invest Urol
; 16(1): 57-61, 1978 Jul.
Article
in English
| MEDLINE
| ID: mdl-99390
Subject(s)
Cations/metabolism , Extracellular Space/metabolism , Muscle, Smooth/metabolism , Animals , Body Water/metabolism , Calcium/metabolism , Dogs , Edetic Acid/metabolism , Female , Magnesium/metabolism , Male , Muscle, Smooth/cytology , Potassium/metabolism , Sodium/metabolism , Urinary Bladder
2.
Invest Urol
; 14(1): 76-8, 1976 Jul.
Article
in English
| MEDLINE
| ID: mdl-955853
ABSTRACT
In vitro detrusor strip experiments show that the presence of calcium ion is essential for spontaneous and bethanechol-induced detrusor contractile activity. 45Ca uptake experiments show that detrusor strips subjected to bethanechol show increased 45Ca uptake with significant decrease in total muscle strip calcium. There is a significant increase in the percentage of calcium exchange, suggesting that calcium efflux has exceeded influx. Kinetic analysis of 45Ca uptake by detrusor strips shows more 45Ca to reside in the slow component of strips following exposure to bethanechol. This suggests that calcium associated with bethanechol-induced contractile activity comes to occupy intracellular or more tightly bound membrane sites.
Subject(s)
Calcium/physiology , Muscle Contraction , Urinary Bladder/physiology , Animals , Bethanechol Compounds/pharmacology , Calcium/deficiency , Calcium/metabolism , Calcium Radioisotopes/metabolism , Dogs , Female , In Vitro Techniques , Ions , Kinetics , Male , Muscle Contraction/drug effects , Muscle, Smooth/ultrastructure , Sarcoplasmic Reticulum/metabolism , Urinary Bladder/drug effects
3.
J Pharmacol Exp Ther
; 188(3): 536-52, 1974 Mar.
Article
in English
| MEDLINE
| ID: mdl-4544587
Subject(s)
Calcium/metabolism , Glycerol/pharmacology , Magnesium/metabolism , Muscles/metabolism , Animals , Anura , Calcium Radioisotopes , Cobalt Radioisotopes , Hypertonic Solutions , In Vitro Techniques , Muscle Contraction/drug effects , Muscles/analysis , Muscles/drug effects , Organ Size , Osmolar Concentration , Potassium/metabolism , Rana pipiens , Sodium/metabolism , Sodium Chloride , Sucrose , Time Factors , Water/analysis
4.
J Pharmacol Exp Ther
; 157(2): 388-405, 1967 Aug.
Article
in English
| MEDLINE
| ID: mdl-6039830
Subject(s)
Lidocaine/pharmacology , Muscle Contraction/drug effects , Muscles/drug effects , Procaine/pharmacology , Tetracaine/pharmacology , Action Potentials/drug effects , Animals , Anura , Caffeine/pharmacology , Carbon Isotopes/metabolism , Drug Synergism , Electrophysiology , Extracellular Space/metabolism , Hydrogen-Ion Concentration , In Vitro Techniques , Lidocaine/metabolism , Muscles/metabolism , Muscles/physiology , Procaine/metabolism
5.
J Pharmacol Exp Ther
; 151(3): 456-63, 1966 Mar.
Article
in English
| MEDLINE
| ID: mdl-5938481