ABSTRACT
A woman with epigastric pain, vomiting, weight loss, and an upper gastrointestinal series showing antral rigidity suggestive of linitis plastica was found to have granulomatous inflammation of the stomach. Additional investigations disclosed more extensive gastrointestinal involvement, with noncaseating granulomas found in esophageal and colonic mucosa, despite normal appearances at endoscopy. Intestinal permeability to [51Cr]EDTA was increased, suggesting intestinal mucosal injury. No specific entity, including disseminated sarcoidosis or Crohn's disease, was diagnosed. This patient with granulomatous gastroenteritis had a clinical and histologic response to medical therapy with prednisone and recurrence of symptoms when prednisone was tapered. Her clinical course was similar to that of previous cases of idiopathic isolated granulomatous gastritis treated nonsurgically. Cases of idiopathic isolated granulomatous gastritis should be categorized as such only if a thorough evaluation has been performed to determine extent of disease, as well as to exclude other entities.
Subject(s)
Gastritis/diagnosis , Gastroenteritis/diagnosis , Granuloma/diagnosis , Adult , Crohn Disease/diagnosis , Diagnosis, Differential , Female , Gastroenteritis/drug therapy , Granuloma/drug therapy , Humans , Prednisone/therapeutic use , Recurrence , Sarcoidosis/diagnosisABSTRACT
A case of extramammary Paget's disease of the scrotum is presented. A patient was diagnosed by biopsy and treated for squamous cell carcinoma in situ of the scrotum. Following surgery, the tumor was found to be extramammary Paget's disease. Management consisted of treatment with 5-fluorouracil followed by wide local excision. The current literature is reviewed briefly.
Subject(s)
Carcinoma in Situ/diagnosis , Carcinoma, Squamous Cell/diagnosis , Genital Neoplasms, Male/diagnosis , Paget Disease, Extramammary/diagnosis , Scrotum , Carcinoma in Situ/pathology , Carcinoma in Situ/surgery , Carcinoma, Squamous Cell/pathology , Carcinoma, Squamous Cell/surgery , Combined Modality Therapy , Fluorouracil/therapeutic use , Genital Neoplasms, Male/pathology , Genital Neoplasms, Male/surgery , Humans , Male , Middle Aged , Paget Disease, Extramammary/pathology , Paget Disease, Extramammary/surgeryABSTRACT
The second reported case of carcinoma of the parathyroid gland in a child 15 years of age or younger is presented. This case is also remarkable in its extremely unusual presentation with seizures, theorized to be associated with hypercalcemia and/or a negative magnesium balance.
